NDLI: Synergistic antitumor effects of transarterial viroembolization for multifocal hepatocellular carcinoma in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Altomonte, Jennifer Braren, Rickmer Schulz, Stephan Marozin, Sabrina Rummeny, Ernst J. Schmid, Roland M. Ebert, Oliver
Description	Country affiliation: Germany Author Affiliation: Altomonte J ( II. Medical Clinic, Technical University of Munich, Munich, Germany.)
Abstract	UNLABELLED: Oncolytic virotherapy is a promising strategy for safe and effective treatment of malignancy. We have reported previously that recombinant vesicular stomatitis virus (VSV) vectors are effective oncolytic agents that can be safely administered via the hepatic artery in immunocompetent rats to treat multifocal hepatocellular carcinoma (HCC), resulting in tumor necrosis and prolonged survival. Though the results were encouraging, complete tumor regression was not observed, which led us to explore alternative approaches to further enhance the efficacy of VSV treatment. Transarterial embolization techniques have been shown to improve the efficiency and tumor selectivity of anticancer treatments. Degradable starch microspheres (DSM) are one such embolic agent that provides transient embolization of the therapeautic agent before being degraded by serum amylases. Here we demonstrate via dynamic contrast-enhanced magnetic resonance imaging that in our rat model of multifocal HCC, DSM injection into the hepatic artery results in a substantial reduction in tumor perfusion of systemically applied contrast agent. VSV, when administered in combination with DSM, results in enhanced tumor necrosis and synergistically prolongs survival when compared with VSV or DSM monotherapy. CONCLUSION: This regimen of viroembolization represents an innovative therapeutic modality that can augment the future development of transarterial oncolytic virus therapy for patients with advanced HCC.
File Format	HTM / HTML
ISSN	02709139
Issue Number	6
Volume Number	48
e-ISSN	15273350
Journal	Hepatology
Language	English
Publisher	Wiley
Publisher Date	2008-12-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Hepatology Carcinoma, Hepatocellular Therapy Virology Embolization, Therapeutic Methods Liver Neoplasms Oncolytic Virotherapy Animals Antigens, Cd31 Metabolism Apoptosis Pathology Cell Line, Tumor Combined Modality Therapy Disease Models, Animal Hepatic Artery Male Microspheres Rats Rats, Inbred Buf Starch Vesiculovirus Genetics Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Hepatology

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