NDLI: The centrosomal protein Tax1 binding protein 2 is a novel tumor suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lai, Wai-Lung Hung, Wing-Yan Wong, Leo Lap-Yan Zhou, Yuan Leong, Veronica Yee-Law Lee, Joyce Man-Fong Ng, Irene Oi-Lin Jin, Dong-Yan Ching, Yick-Pang
Description	Country affiliation: China Author Affiliation: Lai WL ( Department of Anatomy, The University of Hong Kong, Hong Kong, China.)
Abstract	UNLABELLED: Deregulation of cellular-signaling pathways by the inactivation of tumor-suppressor genes is one of the major causes of hepatocellular carcinoma (HCC). In this study, we identified Tax1 binding protein 2 (TAX1BP2) as a novel tumor-suppressor gene in HCC. TAX1BP2 transcript was frequently underexpressed (42.2% with T/NT <0.5; P < 0.03) in HCCs, and underexpression of TAX1BP2 was associated with poorer overall survival rates in patients after surgical resection. An effector domain (ED) for TAX1BP2 tumor-suppressor activity was mapped to the amino-acid residues 267-756. Transient or stable expression of either full-length or ED of TAX1BP2 significantly suppressed HCC cell tumorigenicity through the activation of the p38/p53/p21 pathway. In contrast, silencing of TAX1BP2 by short interfering RNA remarkably suppressed the activation of the p38/p53/p21 pathway. Finally, phosphorylation of TAX1BP2 at serine-763 by cyclin-dependent kinase (CDK)2 abolished the TAX1BP2-mediated p38 activation and tumor-suppressive activity, indicating that TAX1BP2 can adapt CDK2 signaling to the p38/p53/p21 pathway. CONCLUSION: Taken together, our data provide the first evidence that TAX1BP2 is a CDK2-regulated tumor-suppressor gene in HCC and is a novel activator of the p38/p53/p21 pathway.
File Format	HTM / HTML
ISSN	02709139
Issue Number	5
Volume Number	56
e-ISSN	15273350
Journal	Hepatology
Language	English
Publisher	Wiley
Publisher Date	2012-11-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Discipline Hepatology Carcinoma, Hepatocellular Genetics Cyclin-dependent Kinase 2 Metabolism Gene Expression Regulation, Neoplastic Liver Neoplasms Membrane Proteins Pathology Centrosome Cyclin-dependent Kinase Inhibitor P21 Down-regulation Gene Silencing Hep G2 Cells Humans Kaplan-meier Estimate Map Kinase Signaling System Phosphorylation Tumor Suppressor Protein P53 Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Hepatology

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