NDLI: The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila.

Please wait, while we are loading the content...

Year: 2017 Volume: 31

Year: 2016 Volume: 30

Year: 2015 Volume: 29

Year: 2014 Volume: 28

Year: 2013 Volume: 27

Year: 2012 Volume: 26

Year: 2011 Volume: 25

Year: 2010 Volume: 24

Year: 2009 Volume: 23

Year: 2008 Volume: 22

Year: 2007 Volume: 21

Year: 2006 Volume: 20

Year: 2005 Volume: 19

Year: 2004 Volume: 18

Year: 2003 Volume: 17

Year: 2002 Volume: 16

Year: 2001 Volume: 15

Year: 2000 Volume: 14

Year: 1999 Volume: 13

Year: 1998 Volume: 12

Year: 1997 Volume: 11

Year: 1997 Volume: 11 Issue: 24

Year: 1997 Volume: 11 Issue: 23

Year: 1997 Volume: 11 Issue: 22

Conversion of dorsal from an activator to a repressor by the global corepressor Groucho.

The Cdc42 GTPase-associated proteins Gic1 and Gic2 are required for polarized cell growth in Saccharomyces cerevisiae.

Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast.

The Arabidopsis HY5 gene encodes a bZIP protein that regulates stimulus-induced development of root and hypocotyl.

The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis.

Mechanism of synergy between TATA and initiator: synergistic binding of TFIID following a putative TFIIA-induced isomerization.

The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila.

Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae.

Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast.

Mechanism of active site exclusion in a site-specific recombinase: role of the DNA substrate in conferring half-of-the-sites activity.

Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed.

u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila.

Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila.

Year: 1997 Volume: 11 Issue: 21

Year: 1997 Volume: 11 Issue: 18

Year: 1997 Volume: 11 Issue: 17

Year: 1997 Volume: 11 Issue: 16

Year: 1997 Volume: 11 Issue: 15

The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Burke, T. W. Kadonaga, J. T.
Description	Author Affiliation: Burke TW ( Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093-0347 USA.)
Abstract	We analyzed the function of the downstream promoter element (DPE), a distinct 7-nucleotide core promoter element that is approximately 30 nucleotides downstream of the transcription start site of many TATA-box-deficient (TATA-less) promoters in Drosophila. There is a strict requirement for spacing between the Inr and DPE motifs, as an increase or decrease of 3 nucleotides in the distance between the Inr and DPE causes a seven- to eightfold reduction in transcription as well as a significant reduction in the binding of purified TFIID. These results suggest a specific and somewhat rigid interaction of TFIID with the Inr and DPE sequences. Photo-cross-linking analysis of purified TFIID with a TATA-less DPE-containing promoter revealed specific cross-linking of dTAFII60 and dTAFII40 to the DPE, with a higher efficiency of cross-linking to dTAFII60 than to dTAFII40. These data, combined with the previously well-characterized interactions between the two TAFs and their homology to histones H4 and H3, suggest that a dTAFII60-dTAFII40 heterotetramer binds to the DPE. Human and Drosophila transcription factors exhibit essentially the same requirements for DPE sequence and for Inr-DPE spacing. In addition, the TATA-less promoter of the human interferon regulatory factor-1 (IRF-1) gene contains a DPE that is important for transcriptional activity both in vitro and in cultured cells. Hence, these studies provide evidence for a direct role of TAFs in basal transcription of TATA-less DPE-containing genes and collectively indicate that the DPE is, in many respects, a downstream counterpart to the TATA box that is present in Drosophila to humans.
File Format	HTM / HTML
ISSN	08909369
e-ISSN	15495477
Journal	Genes & Development
Issue Number	22
Volume Number	11
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	1997-11-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Drosophila Proteins Drosophila Melanogaster Genetics Promoter Regions, Genetic Tata-binding Protein Associated Factors Transcription Factor Tfiid Transcription Factors Metabolism Animals Binding Sites Cell Line Dna-binding Proteins Gene Expression Regulation Transcription, Genetic Research Support, U.s. Gov't, P.h.s.
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in