NDLI: Caudal, a key developmental regulator, is a DPE-specific transcriptional factor.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Juven-Gershon, Tamar Hsu, Jer-Yuan Kadonaga, James T.
Description	Country affiliation: United States Author Affiliation: Juven-Gershon T ( Section of Molecular Biology, University of California at San Diego, La Jolla, California 92093, USA.)
Abstract	The regulation of gene transcription is critical for the proper development and growth of an organism. The transcription of protein-coding genes initiates at the RNA polymerase II core promoter, which is a diverse module that can be controlled by many different elements such as the TATA box and downstream core promoter element (DPE). To understand the basis for core promoter diversity, we explored potential biological functions of the DPE. We found that nearly all of the Drosophila homeotic (Hox) gene promoters, which lack TATA-box elements, contain functionally important DPE motifs that are conserved from Drosophila melanogaster to Drosophila virilis. We then discovered that Caudal, a sequence-specific transcription factor and key regulator of the Hox gene network, activates transcription with a distinct preference for the DPE relative to the TATA box. The specificity of Caudal activation for the DPE is particularly striking when a BRE(u) core promoter motif is associated with the TATA box. These findings show that Caudal is a DPE-specific activator and exemplify how core promoter diversity can be used to establish complex regulatory networks.
File Format	HTM / HTML
ISSN	08909369
e-ISSN	15495477
DOI	10.1101/gad.1698108
Journal	Genes & Development
Issue Number	20
Volume Number	22
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2008-10-15
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Drosophila Proteins Metabolism Gene Expression Regulation Homeodomain Proteins Promoter Regions, Genetic Genetics Regulatory Elements, Transcriptional Transcription Factor Tfiid Transcription Factors Transcription, Genetic Animals Drosophila Melanogaster Enhancer Elements, Genetic Molecular Sequence Data Rna Polymerase Ii Sequence Homology, Nucleic Acid Tata Box Transfection Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription

The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila.

Different core promoters possess distinct regulatory activities in the Drosophila embryo.

Enhancer-promoter specificity mediated by DPE or TATA core promoter motifs.

Structure-Function Analysis of the Drosophila melanogaster Caudal Transcription Factor Provides Insights into Core Promoter-preferential Activation.

Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network.

Core promoter-selective function of HMGA1 and Mediator in Initiator-dependent transcription

cDNA clone encoding Drosophila transcription factor TFIID.

A core transcriptional network for early mesoderm development in Drosophila melanogaster.

Caudal, a key developmental regulator, is a DPE-specific transcriptional factor.

Similar Documents

TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription

The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFII60 of Drosophila.

Different core promoters possess distinct regulatory activities in the Drosophila embryo.

Enhancer-promoter specificity mediated by DPE or TATA core promoter motifs.

Structure-Function Analysis of the Drosophila melanogaster Caudal Transcription Factor Provides Insights into Core Promoter-preferential Activation.

Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network.

Core promoter-selective function of HMGA1 and Mediator in Initiator-dependent transcription

cDNA clone encoding Drosophila transcription factor TFIID.

A core transcriptional network for early mesoderm development in Drosophila melanogaster.

Caudal, a key developmental regulator, is a DPE-specific transcriptional factor.