NDLI: Krox-20 patterns the hindbrain through both cell-autonomous and non cell-autonomous mechanisms.

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Krox-20 patterns the hindbrain through both cell-autonomous and non cell-autonomous mechanisms.

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Krox-20 patterns the hindbrain through both cell-autonomous and non cell-autonomous mechanisms.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Giudicelli, F. Taillebourg, E. Charnay, P. Gilardi-Hebenstreit, P.
Description	Country affiliation: France Author Affiliation: Giudicelli F ( Unité 368 de l'Institut National de la Santé et de la Recherche Médicale, Ecole Normale Supérieure, 75230 Paris Cedex 05, France.)
Abstract	The Krox-20 gene encodes a zinc finger transcription factor, which has been shown previously, by targeted inactivation in the mouse, to be required for the development of rhombomeres (r) 3 and 5 in the segmented embryonic hindbrain. In the present work, Krox-20 was expressed ectopically in the developing chick hindbrain by use of electroporation. We demonstrate that Krox-20 expression is sufficient to confer odd-numbered rhombomere characteristics to r2, r4, and r6 cells, presumably in a cell-autonomous manner. Therefore, Krox-20, appears as the major determinant of odd-numbered identity within the hindbrain. In addition, we provide evidence for the existence of a non cell-autonomous autoactivation mechanism allowing recruitment of Krox-20-positive cells from even-numbered territories by neighboring Krox-20-expressing cells. On the basis of these observations, we propose that Krox-20 regulates multiple, intertwined steps in segmental patterning: Initial activation of Krox-20 in a few cells leads to the segregation, homogenization, and possibly expansion of territories to which Krox-20 in addition confers an odd-numbered identity.
File Format	HTM / HTML
ISSN	08909369
e-ISSN	15495477
Journal	Genes & Development
Issue Number	5
Volume Number	15
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2001-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Body Patterning Genetics Dna-binding Proteins Gene Expression Regulation, Developmental Rhombencephalon Metabolism Transcription Factors Animals Cell Lineage Chick Embryo Early Growth Response Protein 2 Electroporation Fetal Proteins Homeodomain Proteins Immunohistochemistry Mice Nerve Tissue Proteins Receptor Protein-tyrosine Kinases Receptor, Epha4 Cytology Growth & Development Zinc Fingers Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

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Krox-20 patterns the hindbrain through both cell-autonomous and non cell-autonomous mechanisms

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Krox-20 patterns the hindbrain through both cell-autonomous and non cell-autonomous mechanisms.

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