NDLI: Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.

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Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.

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Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Marinissen, M. J. Chiariello, M. Gutkind, J. S.
Description	Country affiliation: United States Author Affiliation: Marinissen MJ ( Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA.)
Abstract	Small GTP-binding proteins of the Rho-family, Rho, Rac, and Cdc42, have been traditionally linked to the regulation of the cellular actin-based cytoskeleton. Rac and Cdc42 can also control the activity of JNK, thus acting in a molecular pathway transmitting extracellular signals to the nucleus. Interestingly, Rho can also regulate gene expression, albeit by a not fully understood mechanism. Here, we found that activated RhoA can stimulate c-jun expression and the activity of the c-jun promoter. As the complexity of the signaling pathways controlling the expression of c-jun has begun to be unraveled, this finding provided a unique opportunity to elucidate the biochemical routes whereby RhoA regulates nuclear events. We found that RhoA can initiate a linear kinase cascade leading to the activation of ERK6 (p38 gamma), a recently identified member of the p38 family of MAPKs. Furthermore, we present evidence that RhoA, PKN, MKK3/MKK6, and ERK6 (p38 gamma) are components of a novel signal transduction pathway involved in the regulation of gene expression and cellular transformation.
File Format	HTM / HTML
ISSN	08909369
e-ISSN	15495477
Journal	Genes & Development
Issue Number	5
Volume Number	15
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2001-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Map Kinase Signaling System Mitogen-activated Protein Kinases Genetics Rhoa Gtp-binding Protein 3t3 Cells Activating Transcription Factor 2 Animals Blotting, Northern Blotting, Western Calcium-calmodulin-dependent Protein Kinases Metabolism Cell Transformation, Neoplastic Cyclic Amp Response Element-binding Protein Dna-binding Proteins Map Kinase Kinase 3 Map Kinase Kinase 6 Mef2 Transcription Factors Mice Mitogen-activated Protein Kinase 12 Mitogen-activated Protein Kinase Kinases Mutation Myogenic Regulatory Factors Phosphorylation Promoter Regions, Genetic Protein-serine-threonine Kinases Protein-tyrosine Kinases Proto-oncogene Proteins C-jun Transcription Factor Ap-1 Transcription Factors Transcriptional Activation
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

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