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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mika, Franziska Hengge, Regine |
| Description | Country affiliation: Germany Author Affiliation: Mika F ( Institut für Biologie-Mikrobiologie, Freie Universität Berlin, Germany.) |
| Abstract | The general stress sigma factor sigma(S) (RpoS) in Escherichia coli is controlled at the levels of transcription, translation, and proteolysis. Here we demonstrate that the phosphorylated response regulator ArcA is a direct repressor of rpoS transcription that binds to two sites flanking the major rpoS promoter, with the upstream site overlapping an activating cAMP-CRP-binding site. The histidine sensor kinase ArcB not only phosphorylates ArcA, but also the sigma(S) proteolytic targeting factor RssB, and thereby stimulates sigma(S) proteolysis. Thus, ArcB/ArcA/RssB constitute a branched 'three-component system', which coordinates rpoS transcription and sigma(S) proteolysis and thereby maintains low sigma(S) levels in rapidly growing cells. We suggest that the redox state of the quinones, which controls autophosphorylation of ArcB, not only monitors oxygen but also energy supply, and we show that the ArcB/ArcA/RssB system is involved in sigma(S) induction during entry into starvation conditions. Moreover, this induction is enhanced by a positive feedback that involves sigma(S)-dependent induction of ArcA, which further reduces sigma(S) proteolysis, probably by competing with RssB for residual phosphorylation by ArcB. |
| File Format | HTM / HTML |
| ISSN | 08909369 |
| e-ISSN | 15495477 |
| Journal | Genes & Development |
| Issue Number | 22 |
| Volume Number | 19 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2005-11-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Bacterial Outer Membrane Proteins Physiology Bacterial Proteins Biosynthesis Dna-binding Proteins Escherichia Coli Proteins Escherichia Coli Metabolism Membrane Proteins Protein Kinases Repressor Proteins Sigma Factor Transcription Factors Genetics Gene Expression Regulation, Bacterial Hydrolysis Mutation Phosphorylation Phosphotransferases Transcription, Genetic Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology |
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