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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Battesti, Aurelia Hoskins, Joel R. Tong, Song Milanesio, Paola Mann, Jessica M. Kravats, Andrea Tsegaye, Yodit M. Bougdour, Alexandre Wickner, Sue Gottesman, Susan |
| Description | Country affiliation: United States Author Affiliation: Battesti A ( Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892, USA.) |
| Abstract | RpoS, an RNA polymerase σ factor, controls the response of Escherichia coli and related bacteria to multiple stress responses. During nonstress conditions, RpoS is rapidly degraded by ClpXP, mediated by the adaptor protein RssB, a member of the response regulator family. In response to stress, RpoS degradation ceases. Small anti-adaptor proteins--IraP, IraM, and IraD, each made under a different stress condition--block RpoS degradation. RssB mutants resistant to either IraP or IraM were isolated and analyzed in vivo and in vitro. Each of the anti-adaptors is unique in its interaction with RssB and sensitivity to RssB mutants. One class of mutants defined an RssB N-terminal region close to the phosphorylation site and critical for interaction with IraP but unnecessary for IraM and IraD function. A second class, in the RssB C-terminal PP2C-like domain, led to activation of RssB function. These mutants allowed the response regulator to act in the absence of phosphorylation but did not abolish interaction with anti-adaptors. This class of mutants is broadly resistant to the anti-adaptors and bears similarity to constitutively activated mutants found in a very different PP2C protein. The mutants provide insight into how the anti-adaptors perturb RssB response regulator function and activation. |
| File Format | HTM / HTML |
| ISSN | 08909369 |
| e-ISSN | 15495477 |
| DOI | 10.1101/gad.229617.113 |
| Journal | Genes & Development |
| Issue Number | 24 |
| Volume Number | 27 |
| Language | English |
| Publisher | Cold Spring Harbor Laboratory Press |
| Publisher Date | 2013-12-15 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Molecular Discipline Biology__semicolon__developmental Discipline Biology__semicolon__genetics__semicolon__cell Discipline Biology Bacterial Proteins Metabolism Dna-binding Proteins Genetics Escherichia Coli K12 Escherichia Coli Proteins Gene Expression Regulation, Bacterial Transcription Factors Mutation Phosphorylation Protein Structure, Tertiary Research Support, N.i.h., Extramural Research Support, N.i.h., Intramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Developmental Biology |
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