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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kawakami, Hiroshi Maguchi, Hiroyuki Mukai, Tsuyoshi Hayashi, Tsuyoshi Sasaki, Tamito Isayama, Hiroyuki Nakai, Yousuke Yasuda, Ichiro Irisawa, Atsushi Niido, Teitetsu Okabe, Yoshinobu Ryozawa, Shomei Itoi, Takao Hanada, Keiji Kikuyama, Masataka Arisaka, Yoshifumi Kikuchi, Shogo |
| Description | Country affiliation: Japan Author Affiliation: Kawakami H ( Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.) |
| Abstract | BACKGROUND: Wire-guided cannulation (WGC) with a sphincterotome (S) for selective bile duct cannulation (SBDC) has been reported to have a higher success rate and lower incidence of post-ERCP pancreatitis (PEP) than conventional methods in some randomized, controlled trials (RCTs) that were both single center and limited to only a few endoscopists. OBJECTIVE: To estimate the difference in SBDC according to the method and catheter used in a multicenter and multiendoscopist study. DESIGN: A prospective, multicenter RCT with a 2 × 2 factorial design. SETTING: Fifteen referral endoscopy units. PATIENTS: In total, 400 consecutive patients with naive papillae who were candidates for ERCP were enrolled and randomized. INTERVENTIONS: Patients were assigned to 4 groups according to combined catheter (S or catheter [C]) and method (with/without guidewire [GW]). MAIN OUTCOME MEASUREMENTS: Success rate of SBDC performed in 10 minutes, SBDC time, fluoroscopy time, and incidence of complications. RESULTS: There was no significant difference in the SBDC success rate between the groups with and without GW, between C and S, or among the 4 groups (C+GW, C, S+GW, S). WGC had a tendency to significantly shorten cannulation and fluoroscopy times only in approximately 70% of patients in this study in whom SBDC was achieved in 10 minutes or less (P = .036 and .00004, respectively). All 4 groups resulted in similar outcomes in PEP (4%, 5.9%, 2%, and 2.1%, respectively). LIMITATIONS: Non-double-blind study. CONCLUSIONS: WGC appears to significantly shorten cannulation and fluoroscopy times. However, neither the method nor type of catheter used resulted in significant differences in either SBDC success rate or incidence of PEP in this RCT. ( CLINICAL TRIAL REGISTRATION NUMBER: UMIN000002572.). |
| File Format | HTM / HTML |
| ISSN | 00165107 |
| Issue Number | 2 |
| Volume Number | 75 |
| e-ISSN | 10976779 |
| Journal | Gastrointestinal Endoscopy |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-02-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Gastroenterology Catheterization Methods Sphincterotomy, Endoscopic Adult Aged Aged, 80 And Over Bile Ducts Biliary Tract Diseases Diagnosis Adverse Effects Instrumentation Cholangiopancreatography, Endoscopic Retrograde Clinical Competence Female Humans Intention To Treat Analysis Logistic Models Male Middle Aged Pancreatic Diseases Time Factors Journal Article Multicenter Study Randomized Controlled Trial |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Gastroenterology |
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