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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Trivedi, P. P. Tripathi, D. N. Jena, G. B. |
| Description | Country affiliation: India Author Affiliation: Trivedi PP ( Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector-67, SAS Nagar, Punjab 160 062, India. priyankatrvd2@gmail.com) |
| Abstract | Doxorubicin is a widely used chemotherapeutic agent causing serious dose-dependent toxicity to non-target tissues such as testis. Its testicular toxicity is mainly due to the induction of oxidative stress. Hesperetin exerts its beneficial effects against oxidative stress-induced cellular damage. In the present investigation, doxorubicin was administered intraperitoneally at the dose of 4 mg/kg bw/week for a period of 5 consecutive weeks. Hesperetin was administered at the doses of 25, 50 and 100mg/kg bw per oral by gavage for 5 consecutive days in a week for 5 weeks. Animals were sacrificed 1 week after the last injection of doxorubicin. The results of the present study clearly indicate the prevention of oxidative stress, DNA damage and the cellular toxicity by hesperetin treatment as evident from the analysis of biochemical parameters, comet assay, halo assay, Terminal Deoxynucleotidyl Transferase-mediated dUTP Nick End Labeling assay, immunohistochemistry and histology. Hesperetin protection against doxorubicin-induced germ cell toxicity was further evident from the sperm count and sperm head morphological evaluation. Moreover, the role of nuclear factor-kappa B, p38 and caspase-3 on hesperetin-mediated protection against doxorubicin-induced testicular toxicity was also investigated. The present study clearly revealed the amelioration of doxorubicin-induced testicular toxicity by the intervention with hesperetin. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 4 |
| Volume Number | 49 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2011-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Caspase 3 Metabolism Doxorubicin Antagonists & Inhibitors Hesperidin Pharmacology Nf-kappa B Testis Drug Effects P38 Mitogen-activated Protein Kinases Animals Toxicity Immunohistochemistry Lipid Peroxidation Male Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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