NDLI: Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells.

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Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells.

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Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Zhang, Yi Song, Lu Cai, Lin Wei, Renxiong Hu, Hao Jin, Wei
Spatial Coverage	China
Description	Country affiliation: China Author Affiliation: Zhang Y ( Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.)
Abstract	Baicalein is a bioactive flavonoid that is widely used in ancient China. However, its effects on the most common primary malignant bone tumor, osteosarcoma, remain unknown. In the present study, we investigated the effects of baicalein in osteosarcoma cells. Our results indicate baicalein might be an efficacious anti-osteosarcoma drug. We found that baicalein could inhibit cell proliferation in a time- and dose-dependent manner. Additionally, we demonstrated that baicalein promotes osteosarcoma cell apoptosis, and our mechanistic studies suggest that this is mediated by caspase activation, especially caspase-3. We also showed that the down-regulation of Bcl-2 and concurrent increase in Bax and Bim levels contribute to the apoptosis induced by baicalein. In addition, we observed that baicalein induces G1 cell cycle arrest by decreasing cyclin D1 and cyclin-dependent kinase 4 (CDK4). Furthermore, our data verifies that baicalein can reduce osteosarcoma cell adhesion, migration and invasion in vitro, which indicates its potential to inhibit osteosarcoma metastasis. The decrease in expression of matrix metalloproteinases (MMP)-2 and MMP-9 may contribute to the effects of baicalein. Taken together, our results provide evidence that baicalein plays important roles in anti-osteosarcoma therapy, and thus may serve as a novel and efficient candidate agent for osteosarcoma treatment.
File Format	HTM / HTML
ISSN	02786915
Volume Number	53
e-ISSN	18736351
Journal	Food and Chemical Toxicology
Language	English
Publisher	Elsevier
Publisher Date	2013-03-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology__semicolon__nutritional Discipline Sciences Antioxidants Pharmacology Apoptosis Drug Effects Cell Cycle Checkpoints Cell Movement Flavanones Osteosarcoma Drug Therapy Antineoplastic Agents Apoptosis Regulatory Proteins Genetics Metabolism Bone Neoplasms Caspase 3 Cell Adhesion Cell Line, Tumor Cell Proliferation China Cyclin D1 Cyclin-dependent Kinase 4 Down-regulation G1 Phase Cell Cycle Checkpoints Humans Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Membrane Proteins Proto-oncogene Proteins Bcl-2-associated X Protein Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology Food Science

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Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells.

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