NDLI: Modulation of the endogenous antioxidants paraoxonase-1 and urate by pesticide exposure and genetic variants of xenobiotic-metabolizing enzymes.

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Modulation of the endogenous antioxidants paraoxonase-1 and urate by pesticide exposure and genetic variants of xenobiotic-metabolizing enzymes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hernández, Antonio F. Gil, Fernando Lacasaña, Marina Rodríguez-Barranco, Miguel Gómez-Martin, Antonio Lozano, David Pla, Antonio
Description	Author Affiliation: Hernández AF ( Department of Legal Medicine and Toxicology, University of Granada School of Medicine, Granada, Spain. Electronic address: ajerez@ugr.es.)
Abstract	This study evaluated the association between pesticide exposure in farmworkers and plasma levels of the endogenous antioxidants urate and paraoxonase-1 (PON1) enzyme activities (paraoxonase, arylesterase and diazoxonase, three substrate-specific assays for measuring PON1 function) by using generalized estimating equations (GEEs). Decreases in plasma and erythrocyte cholinesterases (BChE and AChE, respectively) were used as biomarkers of pesticide exposure. We also assessed the contribution of genetic polymorphisms of the pesticide-metabolising enzymes PON1, glutathione S-transferases (GST) and cholinesterase variants (BCHE) on plasma levels of endogenous antioxidants and potential gene-environment interactions. A dual effect was observed on paraoxonase depending on the pattern of pesticide exposure. Thus, exposure to anticholinesterase pesticides was associated with decreased paraoxonase activity and urate levels whereas long-term pesticide exposure showed an association with increased paraoxonase activity. Significant interactions were observed between BChE activity and PON1 regulatory region polymorphisms on arylesterase and diazoxonase activities, and between AChE activity (a biomarker for long-term pesticide exposure) and PON1192RR genotype on arylesterase activity. These findings suggest that pesticide exposure may affect plasma antioxidant potential and that relevant gene-pesticide interactions may play a mechanistic role in oxidative stress-induced diseases following pesticide exposure. Nonetheless, more studies are needed to better characterise these interactions.
File Format	HTM / HTML
ISSN	02786915
Volume Number	61
e-ISSN	18736351
Journal	Food and Chemical Toxicology
Language	English
Publisher	Elsevier
Publisher Date	2013-11-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Toxicology__semicolon__nutritional Discipline Sciences Aryldialkylphosphatase Blood Pesticides Toxicity Uric Acid Acetylcholinesterase Genetics Adolescent Adult Agriculture Metabolism Case-control Studies Female Gene-environment Interaction Glutathione Transferase Humans Inactivation, Metabolic Longitudinal Studies Male Middle Aged Occupational Exposure Adverse Effects Polymorphism, Single Nucleotide Young Adult Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Medicine Toxicology Food Science

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