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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Bunel, Valérian Antoine, Marie-Hélène Stévigny, Caroline Nortier, Joëlle Duez, Pierre |
| Description | Author Affiliation: Bunel V ( Laboratory of Experimental Nephrology, Université Libre de Bruxelles (ULB), Brussels, Belgium); Antoine MH ( Laboratory of Experimental Nephrology, Université Libre de Bruxelles (ULB), Brussels, Belgium.); Stévigny C ( Laboratory of Pharmacognosy, Bromatology and Human Nutrition, Université Libre de Bruxelles (ULB), Brussels, Belgium.); Nortier J ( Laboratory of Experimental Nephrology, Université Libre de Bruxelles (ULB), Brussels, Belgium.); Duez P ( Laboratory of Pharmacognosy, Bromatology and Human Nutrition, Université Libre de Bruxelles (ULB), Brussels, Belgium) |
| Abstract | Aristolochic acids (AA) are nephrotoxic agents found in Aristolochia species whose consumption leads to the onset of a progressive tubulointerstitial fibrosis. This AA-nephropathy was first reported during the Belgian outbreak of the 1990's in which more than a hundred patients consumed slimming pills containing an Aristolochia species and Magnolia officinalis. The patients developed an end-stage kidney disease requiring dialysis or transplantation. Magnolol and honokiol are bioactive compounds from M. officinalis known for their potent antioxidant activity. As they can alleviate oxidative stress, we investigated their respective effects on AA-mediated tubulotoxicity using HK-2 cells. Magnolol and honokiol were able to reduce the oxidative stress associated with AA-treatment. Cytotoxicity alleviation was further investigated and overall cell viability measurements unexpectedly revealed that both compounds worsened the survival of AA-treated cells. Flow cytometry analyses of annexin V/PI stained cells indicated that the lignans efficiently prevented AA-induced apoptosis; but favored necrosis. Microscopy observations highlighted extensive vacuolization; other types of cell death, including autophagy, paraptosis or accelerated senescence were excluded. Ki-67 index and cell cycle analysis indicated that both magnolol and honokiol inhibited proliferation by blocking the cell cycle at the G1 phase; they also prevented the AA-induced G2/M arrest. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 87 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Aristolochic Acids Toxicity Biphenyl Compounds Kidney Tubules Cytology Drug Effects Lignans Chemistry Cell Cycle Cell Line Free Radical Scavengers Humans Molecular Structure Oxidative Stress Picrates Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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