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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lee, Sei-Jung Lee, Jin Song, Sooyeon Lim, Kye-Taek |
| Description | Country affiliation: South Korea Author Affiliation: Lee SJ ( Department of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 PLUS Creative Veterinary Research Center, Seoul National University, Seoul 08826, South Korea.); Lee J ( Department of Pathology, School of Medicine, University of California at San Diego La Jolla, CA 92093-0864, USA.); Song S ( Division of Animal Science, Chonnam National University, 77 Yongbong-ro, Gwangju 61186, South Korea.); Lim KT ( Division of Animal Science, Chonnam National University, 77 Yongbong-ro, Gwangju 61186, South Korea. Electronic address: ktlim@chonnam.ac.kr.) |
| Abstract | This study was carried out to investigate the anti-inflammatory potentials of a 38 kDa glycoprotein isolated from Styrax japonica Siebold et al Zuccarini (SJSZ glycoprotein). We found that SJSZ glycoprotein has concentration-dependent scavenging activity against DPPH and hydroxyl radicals in the cell-free systems. In colonic epithelial cells (HCT116 cells), the results showed that SJSZ glycoprotein inhibits the production of reactive oxygen species (ROS) induced by glucose/glucose oxidase (G/GO) in a concentration-dependent manner. Experimental mouse colitis was induced by adding dextran sulfate sodium (DSS) to the drinking water at a concentration of 4% (w/v) for 7 days. We figured out that administration of SJSZ glycoprotein (10 mg/kg) lowers the levels of disease activity index, myeloperoxidase activity, and histological inflammation in DSS-treated mice. In addition, SJSZ glycoprotein inhibited plasmic thiobarbituric acid reactive substances (TBARS) formation, nitric oxide (NO) production, and lactate dehydrogenase (LDH) release, accompanying the inhibition of colonic inflammatory signal proteins (NF-κB, iNOS, and COX-2) and inflammation-related cytokines (IL-1ß, IL-6, and TNF- ). These results indicate that SJSZ glycoprotein inhibits oxidative and pro-inflammatory responses in mouse colitis. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 87 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Colitis Chemically Induced Dextran Sulfate Toxicity Glycoproteins Pharmacology Inflammation Drug Therapy Oxidative Stress Drug Effects Styrax Chemistry Animals Cyclooxygenase 2 Genetics Metabolism Gene Expression Regulation Hct116 Cells Humans L-lactate Dehydrogenase Blood Male Mice Mice, Inbred Icr Nf-kappa B Nitric Oxide Nitric Oxide Synthase Type Ii Reactive Oxygen Species Thiobarbituric Acid Reactive Substances Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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