NDLI: Using reagent-supported thromboelastometry (ROTEM) to monitor haemostatic changes in congenital heart surgery employing deep hypothermic circulatory arrest.

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Year: 2005 Volume: 28

Using reagent-supported thromboelastometry (ROTEM) to monitor haemostatic changes in congenital heart surgery employing deep hypothermic circulatory arrest.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Straub, Andreas Schiebold, Daniela Wendel, Hans Peter Hamilton, Carole Wagner, Thomas Schmid, Eckhard Dietz, Klaus Ziemer, Gerhard
Description	Country affiliation: Germany Author Affiliation: Straub A ( Department of Thoracic, Cardiac and Vascular Surgery, University of Tübingen, Germany.)
Abstract	OBJECTIVE: Cardiac surgery employing cardiopulmonary bypass (CPB) and deep hypothermic circulatory arrest (DHCA) can induce coagulation disturbances and bleeding complications that may be especially severe in infants. A better understanding of the coagulopathy and a quick method for its evaluation would be helpful in the management of patients exposed to CPB and DHCA. This study aimed to monitor coagulation defects in congenital heart surgery using rotational thromboelastometry (ROTEM), standard coagulation tests and platelet flow cytometry. METHODS: The study comprised 10 infants undergoing surgery for congenital heart disease on CPB and DHCA. Blood was sampled at skin incision, after heparinisation during CPB (directly pre- and directly post-DHCA) and after protamine administration post-CPB. ROTEM using different reagents including a heparinase-containing assay to evaluate coagulation during heparinisation, APTT and INR, and flow cytometry to evaluate platelet activation were performed. RESULTS: During CPB, the ROTEM indicated CPB-induced clotting factor depletion and platelet dysfunction that persisted after CPB and heparin neutralisation. ROTEM results were available within 15 min and therefore much faster than standard tests. ROTEM-guided specific blood product treatment resulted in satisfactory coagulatory function. The highest degree of platelet activation was found directly after DHCA. CONCLUSIONS: A major benefit of ROTEM is the quick detection of a developing coagulopathy already during CPB. ROTEM guides quick and specific blood product treatment after CPB, which may decrease bleeding complications in cardiac surgery. The finding of maximal platelet activation directly after DHCA suggests that not only CPB but also hypothermia activates platelets in vivo, thereby contributing to platelet dysfunction.
File Format	HTM / HTML
ISSN	10107940
e-ISSN	1873734X
Journal	European Journal of Cardio-Thoracic Surgery
Issue Number	3
Volume Number	34
Language	English
Publisher	Oxford University Press
Publisher Date	2008-09-01
Publisher Place	Germany
Access Restriction	Open
Subject Keyword	Discipline Cardiology__semicolon__surgery Circulatory Arrest, Deep Hypothermia Induced Heart Defects, Congenital Surgery Thrombelastography Blood Coagulation Disorders Diagnosis Cardiopulmonary Bypass Fibrinogen Metabolism Hematocrit Hemostasis, Surgical Indicators And Reagents Infant Infant, Newborn Monitoring, Intraoperative P-selectin Blood Platelet Aggregation Platelet Count Evaluation Studies
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Surgery Cardiology and Cardiovascular Medicine

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