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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Cau, Elise Quillien, Aurelie Blader, Patrick |
| Description | Country affiliation: France Author Affiliation: Cau E ( Centre de Biologie du Développement, UMR 5547 CNRS/UPS, Université Paul Sabatier Bât. 4R3, Toulouse Cedex 9, France.) |
| Abstract | Manipulation of Notch activity alters neuronal subtype identity in vertebrate neuronal lineages. Nonetheless, it remains controversial whether Notch activity diversifies cell fate by regulating the timing of neurogenesis or acts directly in neuronal subtype specification. Here, we address the role of Notch in the zebrafish epiphysis, a simple structure containing only two neural subtypes: projection neurons and photoreceptors. Reducing the activity of the Notch pathway results in an excess of projection neurons at the expense of photoreceptors, as well as an increase in cells retaining a mixed identity. However, although forced activation of the pathway inhibits the projection neuron fate, it does not promote photoreceptor identity. As birthdating experiments show that projection neurons and photoreceptors are born simultaneously, Notch acts directly during neuronal specification rather than by controlling the timing of neurogenesis. Finally, our data suggest that two distinct signals are required for photoreceptor fate specification: one for the induction of the photoreceptor fate and the other, involving Notch, for the inhibition of projection neuron traits. We propose a novel model in which Notch resolves mixed neural identities by repressing an undesired genetic program. |
| File Format | HTM / HTML |
| ISSN | 09501991 |
| e-ISSN | 14779129 |
| Journal | Development |
| Issue Number | 14 |
| Volume Number | 135 |
| Language | English |
| Publisher | The Company of Biologists |
| Publisher Date | 2008-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Developmental Discipline Biology Epiphyses Nerve Tissue Proteins Genetics Physiology Neurons Photoreceptor Cells Receptors, Notch Zebrafish Animals Animals, Genetically Modified Embryo, Nonmammalian Metabolism Fluorescent Antibody Technique, Indirect Green Fluorescent Proteins Homozygote In Situ Hybridization Models, Neurological Signal Transduction Transgenes Embryology Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Developmental Biology Molecular Biology |
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