NDLI: New insights into the maternal to zygotic transition.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Langley, Alexander R. Smith, James C. Stemple, Derek L. Harvey, Steven A.
Description	Country affiliation: United kingdom Author Affiliation: Langley AR ( MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.); Smith JC ( MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.); Stemple DL ( The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.); Harvey SA ( The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK steve.harvey@sanger.ac.uk.)
Abstract	The initial phases of embryonic development occur in the absence of de novo transcription and are instead controlled by maternally inherited mRNAs and proteins. During this initial period, cell cycles are synchronous and lack gap phases. Following this period of transcriptional silence, zygotic transcription begins, the maternal influence on development starts to decrease, and dramatic changes to the cell cycle take place. Here, we discuss recent work that is shedding light on the maternal to zygotic transition and the interrelated but distinct mechanisms regulating the onset of zygotic transcription and changes to the cell cycle during early embryonic development.
File Format	HTM / HTML
ISSN	09501991
e-ISSN	14779129
Journal	Development
Issue Number	20
Volume Number	141
Language	English
Publisher	The Company of Biologists
Publisher Date	2014-10-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Developmental Discipline Biology Gene Expression Regulation, Developmental Transcription, Genetic Zygote Physiology Animals Apoptosis Cell Cycle Dna Replication Drosophila Melanogaster Embryology Fertilization Gastrula Gene Regulatory Networks Mice Xenopus Laevis Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Molecular Biology

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