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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shi, Dongbo Komatsu, Kouji Hirao, Mayumi Toyooka, Yayoi Koyama, Hiroshi Tissir, Fadel Goffinet, André M. Uemura, Tadashi Fujimori, Toshihiko |
| Description | Country affiliation: Japan Author Affiliation: Shi D ( Division of Embryology, National Institute for Basic Biology, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan.); Komatsu K ( Division of Embryology, National Institute for Basic Biology, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.); Hirao M ( Division of Embryology, National Institute for Basic Biology, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.); Toyooka Y ( Division of Embryology, National Institute for Basic Biology, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan The Graduate University for Advanced Studies, Okazaki, Aichi, 444-8787, Japan.); Koyama H ( Division of Embryology, National Institute for Basic Biology, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan The Graduate University for Advanced Studies, Okazaki, Aichi, 444-8787, Japan.); Tissir F ( Institute of Neuroscience, University of Louvain Medical School, Brussels B1200, Belgium.); Goffinet AM ( Institute of Neuroscience, University of Louvain Medical School, Brussels B1200, Belgium.); Uemura T ( Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan.); Fujimori T ( Division of Embryology, National Institute for Basic Biology, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan The Graduate University for Advanced Studies, Okazaki, Aichi, 444-8787, Japan fujimori@nibb.ac.jp.) |
| Abstract | The oviduct is an important organ in reproduction where fertilization occurs, and through which the fertilized eggs are carried to the uterus in mammals. This organ is highly polarized, where the epithelium forms longitudinal folds along the ovary-uterus axis, and the epithelial multicilia beat towards the uterus to transport the ovulated ova. Here, we analyzed the postnatal development of mouse oviduct and report that multilevel polarities of the oviduct are regulated by a planar cell polarity (PCP) gene, Celsr1. In the epithelium, Celsr1 is concentrated in the specific cellular boundaries perpendicular to the ovary-uterus axis from postnatal day 2. We found a new feature of cellular polarity in the oviduct - the apical surface of epithelial cells is elongated along the ovary-uterus axis. In Celsr1-deficient mice, the ciliary motion is not orchestrated along the ovary-uterus axis and the transport ability of beating cilia is impaired. Epithelial cells show less elongation and randomized orientation, and epithelial folds show randomized directionality and ectopic branches in the mutant. Our mosaic analysis suggests that the geometry of epithelial cells is primarily regulated by Celsr1 and as a consequence the epithelial folds are aligned. Taken together, we reveal the characteristics of the multilevel polarity formation processes in the mouse oviduct epithelium and suggest a novel function of the PCP pathway for proper tissue morphogenesis. |
| File Format | HTM / HTML |
| ISSN | 09501991 |
| e-ISSN | 14779129 |
| Journal | Development |
| Issue Number | 23 |
| Volume Number | 141 |
| Language | English |
| Publisher | The Company of Biologists |
| Publisher Date | 2014-12-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Developmental Discipline Biology Cell Polarity Physiology Epithelial Cells Organogenesis Oviducts Embryology Receptors, G-protein-coupled Metabolism Animals Bromodeoxyuridine Genetics Cell Shape Dna Primers Fluorescence Immunohistochemistry Mice Mice, Knockout Microscopy, Electron, Transmission Microspheres Ultrastructure Reverse Transcriptase Polymerase Chain Reaction Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Developmental Biology Molecular Biology |
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