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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Shimanouchi, Toshinori Kawasaki, Hidenori Fuse, Makoto Umakoshi, Hiroshi Kuboi, Ryoichi |
| Description | Country affiliation: Japan Author Affiliation: Shimanouchi T ( Department of Chemical Science and Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka 560-8531, Japan.) |
| Abstract | Phospholipase C (PLC) is considered to be one of key enzymes for the design of drug delivery system using the endocytosis route, because PLC can catalyze the membrane fusion between cell membranes and phospholipid vehicles (liposomes). Membrane fusion by PLC was then studied under various pHs to model the endosomal environment. The used liposomes were composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), and cholesterol (Ch). The membrane fusion was dominated by the enzymatic reaction at pH 6-7.5. In contrast, the membrane perturbation effect due to the conformational change of PLC could induce the membrane fusion at around pH 4. The maximal value of membrane fusion was observed at around pH 5 for three liposomes in the order of DOPC |
| File Format | HTM / HTML |
| ISSN | 09277765 |
| Volume Number | 103 |
| e-ISSN | 18734367 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-03-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Chemistry Bacillus Cereus Enzymology Endosomes Metabolism Membrane Fusion Type C Phospholipases 1,2-dipalmitoylphosphatidylcholine Chemistry Cholesterol Circular Dichroism Fluoresceins Hydrogen-ion Concentration Hydrophobic And Hydrophilic Interactions Ligands Liposomes Phosphatidylcholines Protein Structure, Secondary Protein Structure, Tertiary Spectrometry, Fluorescence Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Colloid and Surface Chemistry Medicine Physical and Theoretical Chemistry Surfaces and Interfaces Biotechnology |
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