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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Antony, Jacob Joe Sithika, Mohamed Ali Ayisha Joseph, Thomas Amal Suriyakalaa, Udhayaraj Sankarganesh, Arunachalam Siva, Durairaj Kalaiselvi, Seenivasan Achiraman, Shanmugam |
| Description | Country affiliation: India Author Affiliation: Antony JJ ( Department of Environmental Biotechnology, Bharathidasan University, Tiruchirappalli-24, Tamil Nadu, India.) |
| Abstract | Ficus religiosa leaf extract was chosen as a reducing agent to fabricate silver nanoparticles (AgNPs) by a simple, cost-effective and eco-friendly process with the aim of treating Dalton's ascites lymphoma (DAL) in mice model. The formation of synthesized nanoparticles were characterized by UV-visible analysis (UV-vis), Fourier transform infra-red (FT-IR), transmission electron microscopy (TEM), X-ray diffraction (XRD) and zeta potential analyses. A peak at 431nm indicated the surface plasmon resonance of AgNPs. FTIR studies indicated polyphenols and proteins as possible encapsulates. TEM analysis showed particles size in the range of 5-35nm. Healthy Swiss Albino mice (30-35g) were intraperitoneally induced with DAL cells and treated with F. religiosa derived AgNPs at a dose of 50µg/ml. Blood and liver tissues were collected subsequent to dissection and subjected to hematological, biochemical and anticancer assays. Hematological and biochemical analyses revealed revival after treating with F. religiosa derived AgNPs. Antioxidant activity results further proved supportive evidence. The apoptosis inducing effect of AgNPs was observed through acridine orange staining (AO and EB) and DNA fragmentation assay. Anti- angiogenic activity was confirmed by observing vessel development. All these observations indicate that the AgNPs were effective in treatment of DAL. |
| File Format | HTM / HTML |
| ISSN | 09277765 |
| Volume Number | 108 |
| e-ISSN | 18734367 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-08-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Chemistry Antineoplastic Agents Pharmacology Ascites Drug Therapy Ficus Chemistry Liver Drug Effects Lymphoma Metal Nanoparticles Plant Extracts Silver Animals Apoptosis Pathology Dna Fragmentation Disease Models, Animal Blood Supply Male Mice Microscopy, Electron, Transmission Neovascularization, Pathologic Particle Size Plant Leaves Spectroscopy, Fourier Transform Infrared Surface Plasmon Resonance Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Colloid and Surface Chemistry Medicine Physical and Theoretical Chemistry Surfaces and Interfaces Biotechnology |
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