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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kuda, Takashi Kosaka, Misa Hirano, Shino Kawahara, Miho Sato, Masahiro Kaneshima, Tai Nishizawa, Makoto Takahashi, Hajime Kimura, Bon |
| Description | Author Affiliation: Kuda T ( Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato City, Tokyo 108-8477, Japan. Electronic address: kuda@kaiyodai.ac.jp.); Kosaka M ( Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato City, Tokyo 108-8477, Japan.); Hirano S ( Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato City, Tokyo 108-8477, Japan.); Kawahara M ( Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato City, Tokyo 108-8477, Japan.); Sato M ( Kaigen Pharma Co. Ltd., 1-25-18, Okusawa, Otaru 047-0013, Japan.); Kaneshima T ( Department of Food and Cosmetic Sciences, Tokyo University of Agriculture, Abashiri, Japan.); Nishizawa M ( Department of Food and Cosmetic Sciences, Tokyo University of Agriculture, Abashiri, Japan.); Takahashi H ( Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato City, Tokyo 108-8477, Japan.); Kimura B ( Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 4-5-7 Konan, Minato City, Tokyo 108-8477, Japan.) |
| Abstract | Brown algal polysaccharides such as alginate, polymers of uronic acids, and laminaran, beta-1,3 and 1,6-glucan, can be fermented by human intestinal microbiota. To evaluate the effects of these polysaccharides on infections caused by food poisoning pathogens, we investigated the adhesion and invasion of pathogens (Salmonella Typhimurium, Listeria monocytogenes and Vibrio parahaemolyticus) in human enterocyte-like HT-29-Luc cells and in infections caused in BALB/c mice. Both sodium Na-alginate and laminaran (0.1% each) inhibited the adhesion of the pathogens to HT-29-Luc cells by approximately 70-90%. The invasion of S. Typhimurium was also inhibited by approximately 70 and 80% by Na-alginate and laminaran, respectively. We observed that incubation with Na-alginate for 18 h increased the transepithelial electrical resistance of HT-29-Luc monolayer cells. Four days after inoculation with 7 log CFU/mouse of S. Typhimurium, the faecal pathogen count in mice that were not fed polysaccharides (control mice) was about 6.5 log CFU/g while the count in mice that were fed Na-alginate had decreased to 5.0 log CFU/g. The liver pathogen count, which was 4.1 log CFU/g in the control mice, was also decreased in mice that were fed Na-alginate. In contrast, the mice that were fed laminaran exhibited a more severe infection than that exhibited by control mice. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 125 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-10 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Alginates Pharmacology Anti-bacterial Agents Glucans Salmonella Infections Drug Therapy Chemistry Therapeutic Use Animals Enterocytes Drug Effects Microbiology Glucuronic Acid Ht29 Cells Hexuronic Acids Humans Listeria Monocytogenes Mice Mice, Inbred Balb C Salmonella Enterica Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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