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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Straccia, Maria Cristina D'ayala, Giovanna Gomez Romano, Ida Laurienzo, Paola |
| Description | Author Affiliation: Straccia MC ( Institute for Polymers, Composite and Biomaterials, CNR, via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy. Electronic address: mariacristina.straccia@ictp.cnr.it.); d'Ayala GG ( Institute for Polymers, Composite and Biomaterials, CNR, via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy. Electronic address: giovanna.gomez@ictp.cnr.it.); Romano I ( Institute of Biomolecular Chemistry, CNR, via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy. Electronic address: iromano@icb.cnr.it.); Laurienzo P ( Institute for Polymers, Composite and Biomaterials, CNR, via Campi Flegrei 34, Pozzuoli, 80078 Naples, Italy. Electronic address: paola.laurienzo@ictp.cnr.it.) |
| Abstract | In this paper, a controlled gelation of alginate was performed for the first time using ZnCO3 and GDL. Uniform and transparent gels were obtained and investigated as potential wound dressings. Homogeneity, water content, swelling capability, water evaporation rate, stability in normal saline solution, mechanical properties and antibacterial activity were assessed as a function of zinc concentration. Gelation rate increased at increasing zinc content, while a decrease in water uptake and an improvement of stability were found. Release of zinc in physiological environments showed that concentration of zinc released in solution lies below the cytotoxicity level. Hydrogels showed antimicrobial activity against Escherichia coli. The hydrogel with highest zinc content was stabilized with calcium by immersion in a calcium chloride solution. The resulting hydrogel preserved homogeneity and antibacterial activity. Furthermore, it showed even an improvement of stability and mechanical properties, which makes it suitable as long-lasting wound dressing. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 125 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-07-10 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Alginates Chemistry Anti-bacterial Agents Chemical Synthesis Hydrogels Zinc Pharmacology Escherichia Coli Drug Effects Polymerization Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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