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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Michiels, Joris De Vos, Maartje Missotten, Joris Ovyn, Anneke De Smet, Stefaan Van Ginneken, Christa |
| Description | Country affiliation: Belgium Author Affiliation: Michiels J ( Faculty of Biosciences and Landscape Architecture, University College Ghent, Valentin Vaerwyckweg 1, 9000 Ghent, Belgium. joris.michiels@hogent.be) |
| Abstract | The digestive function of low birth weight (LBW) pigs post-weaning has been poorly studied. Therefore, newborns from eleven hyperprolific sows were weighed, weaned at 27·2 d and fed a starter diet until sampling. Sampling was done between 18 and 28 d post-weaning. An LBW piglet (n 19) was defined as a piglet having a birth weight less than 1 kg and less than the lower quartile of litter birth weights. Normal birth weight (NBW) piglets (n 13) were having a birth weight close to the mean litter birth weight. For each piglet, eighty-eight variables were determined. Data were analysed with linear models with type of piglet and litter as predictors. A principal component analysis was performed to determine the most important discriminating variables. In the LBW pig, the development of the digestive tract post-weaning was delayed: lower small-intestinal weight:length ratio due to a thinner tela submucosa and tunica muscularis and a higher secretory capacity, both in the distal jejunum. These observations might be a consequence of lower circulating insulin-like growth factor-1 (IGF-1) concentrations (126 (se 10·0) v. 158 (se 12·0) ng/ml for LBW and NBW, respectively) and a lower density of IGF-1 receptors in the proximal small intestine. Additionally, the plasma antioxidant capacity was lower for the LBW pig. Taken together, in the LBW piglet, the normal gut maturation post-weaning was retarded and this did not seem to be related to the weaning transition as such. |
| File Format | HTM / HTML |
| ISSN | 00071145 |
| Issue Number | 1 |
| Volume Number | 109 |
| e-ISSN | 14752662 |
| Journal | British Journal of Nutrition |
| Language | English |
| Publisher | Cambridge University Press (on behalf of The Nutrition Society) |
| Publisher Date | 2013-01-14 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Nutritional Discipline Sciences Antioxidants Analysis Digestion Down-regulation Fetal Growth Retardation Veterinary Intestine, Small Physiopathology Swine Diseases Blood Animals Birth Weight Crosses, Genetic Metabolism Pathology Gastrointestinal Contents Chemistry Hydrogen-ion Concentration Insulin-like Growth Factor I Intestinal Mucosa Secretion Organ Size Principal Component Analysis Receptor, Igf Type 1 Sus Scrofa Swine Weaning Weight Gain Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
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