NDLI: A multiple-day regimen of parecoxib sodium 20 mg twice daily provides pain relief after total hip arthroplasty.

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A multiple-day regimen of parecoxib sodium 20 mg twice daily provides pain relief after total hip arthroplasty.

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A multiple-day regimen of parecoxib sodium 20 mg twice daily provides pain relief after total hip arthroplasty.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Viscusi, Eugene R. Gimbel, Joseph S. Halder, Andreas M. Snabes, Michael Brown, Mark T. Verburg, Kenneth M.
Description	Country affiliation: United States Author Affiliation: Viscusi ER ( Department of Anesthesiology, Acute Pain Management, Jefferson Medical College of Thomas Jefferson University, 111 S. 11th St., Suite G-8490, Philadelphia, PA 19107, USA. Eugene.viscusi@jefferson.edu)
Abstract	BACKGROUND: This multicenter, multiple-dose, randomized, double-blind, parallel-group study compared the analgesic efficacy and safety of two dosing regimens of parecoxib sodium (parecoxib) versus placebo after total hip arthroplasty. METHODS: On study Day 1, 490 patients received a postoperative initial loading dose of IV parecoxib 40 mg, followed by a re-dose of parecoxib 20 mg in 484 of 490 patients. Subsequently, 479 randomized patients received double-blind treatment with parecoxib 20 mg bid (n = 159), parecoxib 20 mg qd (n = 159) followed by placebo, or placebo (n = 161) on Day 2. RESULTS: Patients treated with parecoxib 20 mg bid reported significantly lower summed pain intensity over 24 h (SPI-24) scores and improved patients' global evaluation of study medication (PGESM) ratings compared with placebo-treated patients on Days 2 to 5 (P < 0.05). For patients treated with parecoxib 20 mg qd, SPI-24 scores were significantly lower on Days 3 and 4 (P < 0.05), and PGESM ratings significantly improved on Day 5 compared with placebo. The incidence of adverse events was similar in all treatment groups with the exception of fever, vomiting and impaired concentration, which were significantly more common in the placebo group compared with one or other of the parecoxib treatment groups (P < 0.05). CONCLUSION: Multiple-day administration of parecoxib 20 mg once or twice daily is effective and generally well tolerated after total hip arthroplasty.
File Format	HTM / HTML
ISSN	00032999
Issue Number	2
Volume Number	107
e-ISSN	15267598
Journal	Anesthesia & Analgesia
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2008-08-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Anesthesiology Analgesics Administration & Dosage Arthroplasty, Replacement, Hip Cyclooxygenase 2 Inhibitors Isoxazoles Pain, Postoperative Drug Therapy Adolescent Adult Aged Aged, 80 And Over Adverse Effects Double-blind Method Drug Administration Schedule Female Humans Male Middle Aged Pain Measurement Patient Satisfaction Comparative Study Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

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