NDLI: Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.

Please wait, while we are loading the content...

Year: 2017 Volume: 124

Year: 2016 Volume: 123

Year: 2016 Volume: 122

Year: 2015 Volume: 121

Year: 2015 Volume: 120

Year: 2014 Volume: 119

Year: 2014 Volume: 118

Year: 2013 Volume: 117

Year: 2013 Volume: 116

Year: 2012 Volume: 115

Year: 2012 Volume: 114

Year: 2011 Volume: 113

Year: 2011 Volume: 112

Year: 2010 Volume: 111

Year: 2010 Volume: 110

Year: 2009 Volume: 109

Year: 2009 Volume: 108

Year: 2008 Volume: 107

Year: 2008 Volume: 107 Issue: 6

Year: 2008 Volume: 107 Issue: 5

Year: 2008 Volume: 107 Issue: 4

Year: 2008 Volume: 107 Issue: 3

Year: 2008 Volume: 107 Issue: 2

We're tired of waiting.

HIT happens: diagnosing and evaluating the patient with heparin-induced thrombocytopenia.

Treatment of anaphylactic shock: where is the evidence?

Progress is precarious.

Does it add up?

The incidence and implications of anti-heparin-platelet factor 4 antibody formation in a pediatric cardiac surgical population.

Urgent cardiac surgery in a patient with a remote history of heparin-induced thrombocytopenia: use of the anti-PF4/heparin ELISA confirmatory test.

The effects of hydroxyethyl starch 130/0.4 (6%) on blood loss and use of blood products in major surgery: a pooled analysis of randomized clinical trials.

The influence of aprotinin and tranexamic acid on platelet function and postoperative blood loss in cardiac surgery.

Thrombelastography-guided factor VIIa therapy in a surgical patient with severe hemophilia and factor VIII inhibitor.

Thromboelastography-guided recombinant factor VIIa administration in a patient with refractory autoimmune idiopathic thrombocytopenia.

Anaphylactic reaction after systemic application of aprotinin triggered by aprotinin-containing fibrin sealant.

Catecholamine-induced cardiomyopathy and pheochromocytoma.

Factors predictive of poor behavioral compliance during inhaled induction in children.

Pediatric mastocytosis: routine anesthetic management for a complex disease.

Antiemetic prophylaxis for postdischarge nausea and vomiting and impact on functional quality of living during recovery in patients with high emetic risks: a prospective, randomized, double-blind comparison of two prophylactic antiemetic regimens.

A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo in preventing postoperative nausea and vomiting over a 72-hour period.

A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo for preventing postoperative nausea and vomiting.

The impact of current antiemetic practices on patient outcomes: a prospective study on high-risk patients.

The relationship between patient risk factors and early versus late postoperative emetic symptoms.

Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor.

Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.

General anesthetics have additive actions on three ligand gated ion channels.

Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility.

Additivity versus synergy: a theoretical analysis of implications for anesthetic mechanisms.

Synergy between Pairs of Competitive Antagonists at Adult Human Muscle Acetylcholine Receptors

Propofol protects hepatic L02 cells from hydrogen peroxide-induced apoptosis via activation of extracellular signal-regulated kinases pathway.

The performance of six pulse oximeters in the environment of neuronavigation.

The effects of auditory evoked potential click sounds on bispectral index and entropy.

An evaluation of gas humidifying devices as a means of intraperitoneal local anesthetic administration for laparoscopic surgery.

Coronary artery stents: Part I. Evolution of percutaneous coronary intervention.

Coronary artery stents: II. Perioperative considerations and management.

Life after death: the aftermath of perioperative catastrophes.

Failed tracheal intubation with the LMA-CTrach in two patients with lingual tonsil hyperplasia.

Intubation bougie dissection of tracheal mucosa and intratracheal airway obstruction.

The intrathoracic blood volume index as an indicator of fluid responsiveness in critically ill patients with acute circulatory failure: a comparison with central venous pressure.

Pulmonary effects of noninvasive ventilation combined with the recruitment maneuver after cardiac surgery.

The pivotal role of vasopressin in refractory anaphylactic shock.

A randomized controlled trial of pudendal nerve block for pain relief after episiotomy.

Random drug testing to reduce the incidence of addiction in anesthesia residents: preliminary results from one program.

A study of cognitive dysfunction in patients having carotid endarterectomy performed with regional anesthesia.

Intravenous dexmedetomidine decreases lung permeability induced by intracranial hypertension in rats.

Anesthetic management of a patient with 3-methylcrotonyl-CoA carboxylase deficiency.

A multiple-day regimen of parecoxib sodium 20 mg twice daily provides pain relief after total hip arthroplasty.

The effect of acupressure at the extra 1 point on subjective and autonomic responses to needle insertion.

The feasibility of patient-controlled paravertebral analgesia for major breast cancer surgery: a prospective, randomized, double-blind comparison of two regimens.

A dose-ranging study of intraarticular midazolam for pain relief after knee arthroscopy.

Modulators of Calcium Influx Regulate Membrane Excitability in Rat Dorsal Root Ganglion Neurons

Prolonged use of high-dose morphine impairs angiogenesis and mobilization of endothelial progenitor cells in mice.

Intrathecal clonidine suppresses phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit in spinal dorsal horn neurons of rats with neuropathic pain.

The effects of varying local anesthetic concentration and volume on continuous popliteal sciatic nerve blocks: a dual-center, randomized, controlled study.

Factors affecting the distribution of neural blockade by local anesthetics in epidural anesthesia and a comparison of lumbar versus thoracic epidural anesthesia.

Valid and relevant outcome measures are critical for objective hypothesis-testing.

Dr. Paul: views through the piperidine ring.

Judgment and risk to patient in study design.

Continuous interscalene block for open shoulder surgery.

A near total spinal anesthetic following a test dose prior to an epidural blood patch.

Ilioinguinal/iliohypogastric blocks: where is the anesthetic injected?

Anomalous brachial plexus anatomy in the supraclavicular region detected by ultrasound.

Gabapentin for the treatment of glossodynia due to an unusual cause.

Valsalva's maneuver to assist delivery of a neurocysticercosis cyst from the fourth ventricle.

Year: 2008 Volume: 107 Issue: 1

Year: 2008 Volume: 106

Year: 2007 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2006 Volume: 102

Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Eger, Edmond I. Tang, Michael Liao, Mark Laster, Michael J. Solt, Ken Flood, Pamela Jenkins, Andrew Raines, Douglas Hendrickx, Jan F. Shafer, Steven L. Yasumasa, Tanifuji Sonner, James M.
Description	Country affiliation: United States Author Affiliation: Eger EI ( Department of Anesthesia, S-455, University of California, San Francisco, CA 94143-0464, USA. egere@anesthesia.ucsf.edu)
Abstract	BACKGROUND: We hypothesized that pairs of inhaled anesthetics having divergent potencies [one acting weakly at minimum alveolar anesthetic concentration (MAC); one acting strongly at MAC] on specific receptors/channels might act synergistically, and that such deviations from additivity would support the notion that anesthetics act on multiple sites to produce anesthesia. METHODS: Accordingly, we studied the additivity of MAC for 11 anesthetic pairs divergently (one weakly, one strongly) affecting a specific receptor/channel at MAC. By 'divergently,' we usually meant that at MAC the more strongly acting anesthetic enhanced or blocked the in vitro receptor or channel at least twice (and usually more) as much as did the weakly acting anesthetic. The receptors/channels included: TREK-1 and TASK-3 potassium channels; and gamma-aminobutyric acid type A, glycine, N-methyl-D-aspartic acid, and acetylcholine receptors. We also studied the additivity of cyclopropane-benzene because the N-methyl-D-aspartic acid blocker MK-801 had divergent effects on the MACs of these anesthetics. We also studied four pairs that included nitrous oxide because nitrous oxide had been reported to produce infraadditivity (antagonism) when combined with isoflurane. RESULTS: All combinations produced a result within 10% of that which would be predicted by additivity except for the combination of isoflurane with nitrous oxide where infraadditivity was found. CONCLUSIONS: Such results are consistent with the notion that inhaled anesthetics act on a single site to produce immobility in the face of noxious stimulation.
File Format	HTM / HTML
ISSN	00032999
Issue Number	2
Volume Number	107
e-ISSN	15267598
Journal	Anesthesia & Analgesia
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2008-08-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Anesthesiology Anesthetics, Inhalation Pharmacology Administration & Dosage Animals Drug Synergism Immobilization Isoflurane Nitrous Oxide Potassium Channels, Tandem Pore Domain Drug Effects Pulmonary Alveoli Metabolism Rats Rats, Sprague-dawley Receptors, Cholinergic Receptors, Gaba Receptors, N-methyl-d-aspartate Journal Article Research Support, N.i.h., Extramural
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in