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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Li, Hongda Chen, Tie Jin, Longyi Kan, Yuhe Yin, Bingzhu |
| Description | Author Affiliation: Li H ( Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules of the Ministry of Education, Department of Chemistry, Yanbian University, Yanji 133002, PR China); Chen T ( Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules of the Ministry of Education, Department of Chemistry, Yanbian University, Yanji 133002, PR China.); Jin L ( Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules of the Ministry of Education, Department of Chemistry, Yanbian University, Yanji 133002, PR China.); Kan Y ( Jiangsu Province Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian 223300, PR China. Electronic address: yhkan.cn@gmail.com.); Yin B ( Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules of the Ministry of Education, Department of Chemistry, Yanbian University, Yanji 133002, PR China. Electronic address: zqcong@ybu.edu.cn.) |
| Abstract | In this study, we synthesized CTB and CB probes based on doubly activated Michael acceptors to selectively detect cyanide (CN(-)) anions through a one-step condensation reaction of coumarinyl acrylaldehyde with the corresponding derivatives of malonyl urea (thiourea). Through the conjugated addition of CN(-) to the ß-site of the Michael acceptor, both probes displayed colorimetric and fluorometric dual-modal responses that were highly reactive and selective. CTB generates an active fluorescent response, whereas CB displays a ratiometric fluorescent response. The fluorescent signal of the probes reached its maximum given only 1 CN(-) equivalent and the signal change was linearly proportional to CN(-) concentrations ranging from 0 to 5 µM with the detection limits 18 and 23 nM, respectively. The reaction rate of the probes is highly dependent on the methylene acidity of malonyl urea derivatives. Thus, the response rate of CTB to CN(-) is 1.2-fold faster than that of CB, and the response rate of CB to CN(-) is 1.2-fold faster than that of the previously examined CM. We then verified the highly reactive nature of the ß-site of the probes through density functional reactivity theory calculations. In addition, according to proof-of-concept experiments, these probes may be applied to analyze CN(-) contaminated water and biomimetic samples. Finally, cell cytotoxicity and bioimaging studies revealed that the probes were cell-permeable and could be used to detect CN(-) with low cytotoxicity. |
| File Format | HTM / HTML |
| ISSN | 00032670 |
| Volume Number | 852 |
| e-ISSN | 18734324 |
| Journal | Analytica Chimica Acta |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-12-10 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Colorimetry Methods Cyanides Analysis Fluorescent Dyes Chemistry Fluorometry Optical Imaging Hela Cells Humans Limit Of Detection Models, Molecular Molecular Imaging Thiourea Evaluation Studies Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Environmental Chemistry Analytical Chemistry Biochemistry |
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