NDLI: Let Sleeping Dogs Lie—Unleashing the Transforming Power of Dormant HPV

Please wait, while we are loading the content...

Cyclin-Dependent Kinases as Drug Targets for Cell Growth and Proliferation Disorders. A Role for Systems Biology Approach in Drug Development. Part II—CDKs as Drug Targets in Hypertrophic Cell Growth. Modelling of Drugs Targeting CDKs

Polymorphism of Beta-Lactoglobulin Coding and 5′-Flanking Regions and Association with Milk Production Traits

Experimental Confirmation of the Bruchidae Natural Parasitism Efficacy using an Innovative Device, Friendly to the Environment

Growth of Trametes Versicolor in Nitro and Hydroxyl Phenol Derivatives

Metals Concentration and Accumulation in Several Aquatic Macrophytes

Green Algae Can Modulate the Genotoxic Action of Cadmium in Human Lymphocytes

Identification of ISSR Markers for Studying the Biodiversity of Bulgarian Representatives of Genus Orobanche Subsection Minores

Probiotic and Antioxidative Properties of L. Lactis LL27 Isolated from Milk

Producing Functional Soy-Based Yogurt Incubated with Bifidobacterium Longum SPM1205 Isolated from Healthy Adult Koreans

Antibacterial and Antitumor Activities of Some Wild Fruits Grown in Turkey

Partial 9P Monosomy and Partial 8Q Trisomy by Adjacent 1 Segregation of Balanced Paternal Translocation Revealed by Molecular Karyotyping

Histopathologic Effects of Glass Ionomer Bone Cements Application to Maxillofacial Area: An Experimental Study in Rabbits

Studies Regarding the In Vitro Wound Healing Potential of Mouse Dental Pulp Stem-Like Progenitor Cells

Antiviral Potential of a Proteolytic Inhibitor from Streptomyces Chromofuscus 34–1

In Silico Structural Determination of GPAT Enzyme from Ostreococcus Lucimarinus for Biotechnological Application of Microalgal Biofuel Production

Integrating a Bioethics Course Into Undergraduate Biology Education

Economic Analysis 20 Years after the Introduction of Universal HBV Immunisation in Bulgaria

Let Sleeping Dogs Lie—Unleashing the Transforming Power of Dormant HPV

Content Provider	Taylor & Francis Online
Author	Petkova, Rumena Yemendzhiev, Husein Kalvatchev, Zlatko Tsekov, Iliya
Abstract	The rate of infection with human papillomavirus (HPV) worldwide is about 80% of the adult population. Anogenital HPV infections are usually transient and cause no lasting damage. In about 15–20% of the cases, however, the HPV infection may persist and in about 1% it may cause transformation of the infected epithelium that might subsequently progress to overt cervical cancer. The hallmark of the malignant transformation is the integration of the viral genome into the host cell genome, resulting in upregulation of the transcription of the viral oncoproteins E6 and E7. The latter are expressed early in the course of the infection, interacting with the major regulators of the cell cycle progression so as to retain the host cell in a state favourable for the replication of the viral genome. Among the crucial cellular partners in the neoplastic transformation of HPV-infected cells are tumour-suppressor proteins such as p53 and pRb, products of protooncogenes such as p21/WAF1, chromatin structure modifiers such as HMGA1, and controllers of the cellular senescence such as the telomerase complex. The high-risk types of HPV seem to have developed mechanisms capable of evading or disabling virtually any defence. Nature has put in place against cancerous transformation, which could account for the high incidence of cervical dysplasia and cervical cancer despite the efforts the modern medicine and healthcare puts into screening programmes, prevention and therapy. The role of the deregulation of the expression of each of these groups of participants in the pathogenesis of activation of persistent dormant infection is reviewed and their impact on the risk for progression to higher grades of cervical intraepithelial neoplasia (CIN) and development of cervical cancer is assessed.
Starting Page	2689
Ending Page	2694
Page Count	6
File Format	PDF HTM / HTML
ISSN	13102818 13143530
DOI	10.5504/BBEQ.2011.0148
Journal	Biotechnology & Biotechnological Equipment
Volume Number	26
Issue Number	1
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-04-16
Access Restriction	Open
Subject Keyword	HMGA HPV Cervical cancer E6/E7 oncoproteins
Content Type	Text
Subject	Biotechnology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites

The role of HPV E6 and E7 oncoproteins in HPV-associated cervical carcinogenesis.

RIPOR2 Expression Decreased by HPV-16 E6 and E7 Oncoproteins: An Opportunity in the Search for Prognostic Biomarkers in Cervical Cancer.

Human Papillomavirus E6 and E7: The Cervical Cancer Hallmarks and Targets for Therapy

Kaempferide induces apoptosis in cervical cancer by attenuating the HPV oncoproteins, E6 and E7

The Role of HPV E6 and E7 Oncoproteins in HPV-associated Cervical Carcinogenesis

Feasibility study of a human papillomavirus E6 and E7 oncoprotein test for the diagnosis of cervical precancer and cancer

The Efficacy of Therapeutic DNA Vaccines Expressing the Human Papillomavirus E6 and E7 Oncoproteins for Treatment of Cervical Cancer: Systematic Review

AIB1 is a novel target of the high-risk HPV E6 protein and a biomarker of cervical cancer progression.

Let Sleeping Dogs Lie—Unleashing the Transforming Power of Dormant HPV

Similar Documents

Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites

The role of HPV E6 and E7 oncoproteins in HPV-associated cervical carcinogenesis.

RIPOR2 Expression Decreased by HPV-16 E6 and E7 Oncoproteins: An Opportunity in the Search for Prognostic Biomarkers in Cervical Cancer.

Human Papillomavirus E6 and E7: The Cervical Cancer Hallmarks and Targets for Therapy

Kaempferide induces apoptosis in cervical cancer by attenuating the HPV oncoproteins, E6 and E7

The Role of HPV E6 and E7 Oncoproteins in HPV-associated Cervical Carcinogenesis

Feasibility study of a human papillomavirus E6 and E7 oncoprotein test for the diagnosis of cervical precancer and cancer

The Efficacy of Therapeutic DNA Vaccines Expressing the Human Papillomavirus E6 and E7 Oncoproteins for Treatment of Cervical Cancer: Systematic Review

AIB1 is a novel target of the high-risk HPV E6 protein and a biomarker of cervical cancer progression.

Let Sleeping Dogs Lie—Unleashing the Transforming Power of Dormant HPV