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RIPOR2 Expression Decreased by HPV-16 E6 and E7 Oncoproteins: An Opportunity in the Search for Prognostic Biomarkers in Cervical Cancer.
| Content Provider | Europe PMC |
|---|---|
| Author | Olmedo-Nieva, Leslie Muñoz-Bello, J. Omar Martínez-Ramírez, Imelda Martínez-Gutiérrez, Antonio Daniel Ortiz-Pedraza, Yunuen González-Espinosa, Claudia Madrid-Marina, Vicente Torres-Poveda, Kirvis Bahena-Roman, Margarita Lizano, Marcela |
| Editor | Aguilar-Lemarroy, Adriana Jave-Suárez, Luis Felipe |
| Copyright Year | 2022 |
| Abstract | High-risk human papillomavirus (HPV) infection is the main risk factor for cervical cancer (CC) development, where the continuous expression of E6 and E7 oncoproteins maintain the malignant phenotype. In Mexico, around 70% of CC cases are diagnosed in advanced stages, impacting the survival of patients. The aim of this work was to identify biomarkers affected by HPV-16 E6 and E7 oncoproteins that impact the prognosis of CC patients. Expression profiles dependent on E6 and E7 oncoproteins, as well as their relationship with biological processes and cellular signaling pathways, were analyzed in CC cells. A comparison among expression profiles of E6- and E7-expressing cells and that from a CC cohort obtained from The Cancer Genome Atlas (TCGA) demonstrated that the expression of 13 genes impacts the overall survival (OS). A multivariate analysis revealed that the downregulated expression of RIPOR2 was strongly associated with a worse OS. RIPOR2, including its transcriptional variants, were overwhelmingly depleted in E6- and E7-expressing cells. Finally, in a Mexican cohort, it was found that in premalignant cervical lesions, RIPOR2 expression decreases as the lesions progress; meanwhile, decreased RIPOR2 expression was also associated with a worse OS in CC patients. |
| Journal | Cells |
| Volume Number | 11 |
| PubMed Central reference number | PMC9740487 |
| Issue Number | 23 |
| PubMed reference number | 36497200 |
| e-ISSN | 20734409 |
| DOI | 10.3390/cells11233942 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-12-06 |
| Access Restriction | Open |
| Rights License | Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). © 2022 by the authors. |
| Subject Keyword | RIPOR2 prognostic biomarker HPV cervical cancer HPV-16 E6 and E7 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry, Genetics and Molecular Biology |
