NDLI: Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders: Microbial Ecology in Health and Disease: Vol 23, No 1

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Molecular ecology in Health and Disease

Intestinal cytochromes P450 regulating the intestinal microbiota and its probiotic profile

Gut indigenous microbiota and epigenetics

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Editorial: The gut and the brain – with focus on autism spectrum disorders: Microbial Ecology in Health and Disease: Vol 23, No 1

A true case story: Microbial Ecology in Health and Disease: Vol 23, No 1

Longitudinal high-risk sibling studies of autism spectrum disorder

Autism spectrum disorder, functional MRI and MR spectroscopy: possibilities and challenges: Microbial Ecology in Health and Disease: Vol 23, No 1

The gut: a triggering place for autism – possibilities and challenges

Commensal communication to the brain: pathways and behavioral consequences

Peptides’ role in autism with emphasis on exorphins: Microbial Ecology in Health and Disease: Vol 23, No 1

Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders: Microbial Ecology in Health and Disease: Vol 23, No 1

Should autism be considered a canary bird telling that Homo sapiens may be on its way to extinction?

Abstracts from the Joint 17th ISG/34th SOMED Meeting in Yokohama, 1922 May 2011 - complete supplement: Microbial Ecology in Health and Disease: Vol 23, No 1

Abstracts from the Joint 17th ISG/34th SOMED Meeting in Yokohama, 19-22 May 2011

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Defining microbiota for developing new probiotics

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Nutrition economic evaluation of allergy treatment in infants and children: background for probiotic studies: Microbial Ecology in Health and Disease: Vol 23, No 1

Nutrition economics: towards comprehensive understanding of the benefits of nutrition: Microbial Ecology in Health and Disease: Vol 23, No 1

Fermented milk containing Lactobacillus GG alleviated DSS-induced colitis in mice and activated epidermal growth factor receptor and Akt signaling in intestinal epithelial cells: Microbial Ecology in Health and Disease: Vol 23, No 1

Abstract: Overview of technology developments in probiotic field: Microbial Ecology in Health and Disease: Vol 23, No 1

Abstract: Prebiotics and probiotics – the importance of branding

Abstract: Probiotics and atherosclerosis – a new challenge?

Abstract: Probiotics and dental caries

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Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders: Microbial Ecology in Health and Disease: Vol 23, No 1

Content Provider	Taylor & Francis Online
Author	MacFabe, Derrick F.
Abstract	Recent evidence suggests potential, but unproven, links between dietary, metabolic, infective, and gastrointestinal factors and the behavioral exacerbations and remissions of autism spectrum disorders (ASDs). Propionic acid (PPA) and its related short-chain fatty acids (SCFAs) are fermentation products of ASD-associated bacteria (Clostridia, Bacteriodetes, Desulfovibrio). SCFAs represent a group of compounds derived from the host microbiome that are plausibly linked to ASDs and can induce widespread effects on gut, brain, and behavior. Intraventricular administration of PPA and SCFAs in rats induces abnormal motor movements, repetitive interests, electrographic changes, cognitive deficits, perseveration, and impaired social interactions. The brain tissue of PPA-treated rats shows a number of ASD-linked neurochemical changes, including innate neuroinflammation, increased oxidative stress, glutathione depletion, and altered phospholipid/acylcarnitine profiles. These directly or indirectly contribute to acquired mitochondrial dysfunction via impairment in carnitine-dependent pathways, consistent with findings in patients with ASDs. Of note, common antibiotics may impair carnitine-dependent processes by altering gut flora favoring PPA-producing bacteria and by directly inhibiting carnitine transport across the gut. Human populations that are partial metabolizers of PPA are more common than previously thought. PPA has further bioactive effects on neurotransmitter systems, intracellular acidification/calcium release, fatty acid metabolism, gap junction gating, immune function, and alteration of gene expression that warrant further exploration. These findings are consistent with the symptoms and proposed underlying mechanisms of ASDs and support the use of PPA infusions in rats as a valid animal model of the condition. Collectively, this offers further support that gut-derived factors, such as dietary or enteric bacterially produced SCFAs, may be plausible environmental agents that can trigger ASDs or ASD-related behaviors and deserve further exploration in basic science, agriculture, and clinical medicine.
File Format	PDF HTM / HTML
Journal	Microbial Ecology in Health and Disease
Volume Number	23
Issue Number	1
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-08-24
Access Restriction	Open
Subject Keyword	Autism Mitochondria Clostridia Desulfovibrio Propionic acid Butyric acid Carnitine Neuroinflammation Oxidative stress Glutathione Gap junctions Microbiome PUFA Epigenetics
Content Type	Text
Resource Type	Article

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