NDLI: Virulence factors and antibiotic susceptibility in enterococci isolated from oral mucosal and deep infections

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Virulence factors and antibiotic susceptibility in enterococci isolated from oral mucosal and deep infections

Content Provider	Taylor & Francis Online
Author	Dahlén, Gunnar Almståhl, Annica Blomqvist, Susanne Carlén, Anette
Abstract	Objective This study evaluates the presence of virulence factors and antibiotic susceptibility among enterococcal isolates from oral mucosal and deep infections. Methods Forty-three enterococcal strains from oral mucosal lesions and 18 from deep infections were isolated from 830 samples that were sent during 2 years to Oral Microbiology, University of Gothenburg, for analysis. The 61 strains were identified by 16S rDNA, and characterized by the presence of the virulence genes efa A (endocarditis gene), gel E (gelatinase gene), ace (collagen binding antigen gene), asa (aggregation substance gene), cyl A (cytolysin activator gene) and esp (surface adhesin gene), tested for the production of bacteriocins and presence of plasmids. MIC determination was performed using the E-test method against the most commonly used antibiotics in dentistry, for example, penicillin V, amoxicillin and clindamycin. Vancomycin was included in order to detect vancomycin-resistant enterococci (VRE) strains. Results Sixty strains were identified as Enterococcus faecalis and one as Enterococcus faecium. All the virulence genes were detected in more than 93.3% (efa A and esp) of the E. faecalis strains, while the presence of phenotypic characteristics was much lower (gelatinase 10% and hemolysin 16.7%). Forty-six strains produced bacteriocins and one to six plasmids were detected in half of the isolates. Conclusions Enterococcal strains from oral infections had a high virulence capacity, showed bacteriocin production and had numerous plasmids. They were generally susceptible to ampicillins but were resistant to clindamycin, commonly used in dentistry, and no VRE-strain was found.
File Format	PDF HTM / HTML
ISSN	20002297
DOI	10.3402/jom.v4i0.10855
Journal	Journal of Oral Microbiology
Volume Number	4
Issue Number	1
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-02-22
Access Restriction	Open
Subject Keyword	Enterococci Oral mucosal infections Opportunistic infections Antibiotic susceptibility Virulence
Content Type	Text
Resource Type	Article
Subject	Microbiology (medical) Dentistry Infectious Diseases 3500/3501

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