NDLI: Efficacy of NSAIDs for the prevention of acute mountain sickness: a systematic review and meta-analysis

Please wait, while we are loading the content...

Volume: 4 Issue: 5

Volume: 4 Issue: 4

Efficacy of NSAIDs for the prevention of acute mountain sickness: a systematic review and meta-analysis

Drug-induced visceral angioedema

Real-time use of the iPad by third-year medical students for clinical decision support and learning: a mixed methods study

Spontaneous coronary artery dissection causing acute coronary syndrome in a young patient without risk factors

Spontaneous coronary artery dissection: a case series and literature review

Evaluation of pure ground glass pulmonary nodule: a case report

Starvation marrow – gelatinous transformation of bone marrow

Insulinoma: A rare cause of hypoglycemia in a young female

Surprising cause of dysphagia in an elderly male

Lime-induced phytophotodermatitis

Volume: 4 Issue: 3

Volume: 4 Issue: 2

Volume: 4 Issue: 1

Efficacy of NSAIDs for the prevention of acute mountain sickness: a systematic review and meta-analysis

Content Provider	Taylor & Francis Online
Author	Giri, Smith Karmacharya, Paras Pathak, Ranjan Aryal, Madan R. Pandit, Anil
Abstract	BackgroundAcute mountain sickness (AMS) can occur in anyone going to a high altitude. Non-steroidal anti-inflammatory drugs (NSAIDs) have been studied for the prevention of AMS with mixed results. In this systematic review, we analyze all existing data on the use of NSAIDs to prevent AMS using the Lake Louise Scoring System (LLSS) in different randomized clinical trials (RCTs).MethodsElectronic literature searches for relevant studies were identified through MEDLINE, EMBASE, SCOPUS, and Cochrane library up to June 2013. RCTs involving NSAIDs compared to placebo in patients undergoing ascent to a height of at least 3,800 m were included. Odds ratios (OR) were calculated and combined using fixed-effect model meta-analysis if I 2=0%. Differences between groups were calculated using the inverse variance of the standard mean differences. Between-study heterogeneity was assessed using the I 2 statistics.ResultsIn three clinical trials involving 349 patients, AMS using LLSS occurred in 26.92% of patients on NSAIDs and 43.71% on placebo (OR 0.43; CI [confidence interval] 0.27–0.69, I 2=0%, p=0.0005), NNT=6. Minor outcome of end point Spo2 was not significant in the two groups (IV=0.74; 95% CI −0.20–1.69, I 2=81%, p=0.12). Similarly, a change in Spo2 from baseline was also not significant in the two groups (IV=0.05; 95% CI −0.28–0.37, I 2=44%, p=0.78).ConclusionNSAIDs might be a safe and effective alternative for the prevention of AMS. However, further larger population studies and studies comparing NSAIDs to acetazolamide and dexamethasone in the future may provide further data to its relative efficacy.
File Format	PDF HTM / HTML
ISSN	20009666
DOI	10.3402/jchimp.v4.24927
Journal	Journal of Community Hospital Internal Medicine Perspectives
Volume Number	4
Issue Number	4
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-09-29
Access Restriction	Open
Subject Keyword	Altitude sickness Acute mountain sickness Anti-inflammatory agents Non-steroidal Ibuprofen Headache
Content Type	Text
Resource Type	Article
Subject	Internal Medicine

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in