NDLI: Prophylaxis of ibuprofen in acute mountain sickness: A protocol for systematic review and meta-analysis.

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Prophylaxis of ibuprofen in acute mountain sickness: A protocol for systematic review and meta-analysis.

Content Provider	Europe PMC
Author	Yi, Hai Wang, Kuiying Gan, Xinyu Li, Li Zhang, Qian Xiang, Jiao Yuan, Xiuwei Zhang, Yugang Wang, Yonghua
Copyright Year	2020
Abstract	AbstractBackground:Acute mountain sickness (AMS) is the effect when people accessing high altitude in a short period of time. As a cyclooxygenase (COX) inhibitor, ibuprofen could alleviate the symptoms of AMS. However, whether it can prevent AMS or not is still controversial. It is necessary to perform a meta-analysis to evaluate the role of ibuprofen in AMS prophylaxis.Methods:PubMed, EMBASE, Medline, ISI Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) will be searched for the relevant published studies that explored the value of ibuprofen in AMS prophylaxis from inception to October 2020. The data will be independently extracted by 2 researchers. Risk of bias will be evaluated based on Cochrane risk of bias assessment tool. Heterogeneity among the included studies will be evaluated by χ2 and I2 values. The meta-analysis was conducted by RevMan software version 5.3.Results:This study will evaluate the role of ibuprofen in AMS prophylaxis.Conclusion:This study will summarize the current evidence of ibuprofen in AMS prophylaxis, which could further guide the recommendation in prevention of AMS.Open Science Framework (OSF) registration number: October 8, 2020. osf.io/n3mjt.
ISSN	00257974
Journal	Medicine
Volume Number	99
PubMed Central reference number	PMC7668505
Issue Number	46
PubMed reference number	33181710
e-ISSN	15365964
DOI	10.1097/md.0000000000023233
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2020-11-01
Publisher Place	Hagerstown, MD
Access Restriction	Open
Rights License	This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.
Subject Keyword	acute mountain sickness ibuprofen prophylaxis systematic review meta-analysis
Content Type	Text
Resource Type	Article
Subject	Medicine

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