NDLI: Against the stream: relevance of gluconeogenesis from fatty acids for natives of the arctic regions

Please wait, while we are loading the content...

Volume 77, 2018

Volume 76, 2017

Volume 75, 2016

Volume 74, 2015

Volume 73, 2014

Volume 72, 2013

Volume 71, 2012

Volume: 12 Issue: 2

Volume: 12 Issue: 1

IJCH Successfully Completes Transition Year

IJCH Enters a New Era

Breast cancer in the Arctic – changes over the past decades

A decade of research in Inuit children, youth, and maternal health in Canada: areas of concentrations and scarcities

Climate change and zoonotic infections in the Russian Arctic

Obesity studies in the circumpolar Inuit: a scoping review

Self-rated health and ethnicity: focus on indigenous populations

Alcohol in Greenland 1951–2010: consumption, mortality, prices

Design and methods of the Adult Inuit Health Survey 2007–2008

Daily variations in ambulance calls for selected causes in Arkhangelsk, Russia: potential role of excessive alcohol consumption on weekends

Teaching wilderness first aid in a remote First Nations community: the story of the Sachigo Lake Wilderness Emergency Response Education Initiative

Population-based study of high plasma C-reactive protein concentrations among the Inuit of Nunavik

Forging a new legacy of trust in research with Alaska Native college students using CBPR

Explaining reduction of pedestrian–motor vehicle crashes in Arkhangelsk, Russia, in 2005–2010

Victimisation and PTSD in a Greenlandic youth sample

A research review: exploring the health of Canada's Aboriginal youth

Poor self-reported health and its association with biomarkers among Canadian Inuit

Socioeconomic characteristics and health outcomes in Sami speaking municipalities and a control group in northern Norway

A Wellness Course for Community Health Workers in Alaska: “wellness lives in the heart of the community”

Snow crab allergy and asthma among Greenlandic workers – a pilot study

Suicidal ideation among Métis adult men and women – associated risk and protective factors: findings from a nationally representative survey

The role of Indigenous knowledge in environmental health risk management in Yukon, Canada

Frequent use of primary health care service in Greenland: an opportunity for undiagnosed disease case-finding

Traditional food consumption is associated with higher nutrient intakes in Inuit children attending childcare centres in Nunavik

Higher body mass, older age and higher monounsaturated fatty acids intake reflect better quantitative ultrasound parameters in Inuit preschoolers

The health of young Swedish Sami with special reference to mental health

Survival of Sami cancer patients

Coming of age: how young women in the Northwest Territories understand the barriers and facilitators to positive, empowered, and safer sexual health

Innovative primary care delivery in rural Alaska: a review of patient encounters seen by community health aides

Prevalence of the use of antihypertensive medications in Greenland: a study of quality of care amongst patients treated with antihypertensive drugs

Temporal trends in Inuit, First Nations and non-Aboriginal birth outcomes in rural and northern Quebec

The health of Inuit children under age 6 in Canada

The Northern Norway mother-and-child contaminant cohort study: implementation, population characteristics and summary of dietary findings

Modern contact investigation methods for enhancing tuberculosis control in Aboriginal communities

Living conditions, quality of life, adherence and treatment outcome in Greenlandic HIV patients

Alaska Native people's perceptions, understandings, and expectations for research involving biological specimens

Incidence of pancreatic cancer in Greenland 2000–2010

Assessment of consumption of marine food in Greenland by a food frequency questionnaire and biomarkers

Cancer patterns in Inuit Nunangat: 1998–2007

How occupational health is assessed in mine workers in Murmansk Oblast

Fatal hypothermia: an analysis from a sub-arctic region

Increasing rates of diabetes amongst status Aboriginal youth in Alberta, Canada

A traditional Sami diet score as a determinant of mortality in a general northern Swedish population

Association between socioeconomic status and overweight and obesity among Inuit adults: International Polar Year Inuit Health Survey, 2007–2008

Sense of coherence and self-reported health among Roma people in Sweden – a pilot study

Room for improvement in diabetes care among First Nations in northern Quebec (Eeyou Istchee): reasonable management of glucose but poor management of complications

High prevalence of lactase non-persistence among indigenous nomadic Nenets, north-west Russia

Treatment eligibility in Alaska Native and American Indian persons with hepatitis C virus infection

Mycoplasma genitalium presence, resistance and epidemiology in Greenland

Mammographic screening in Sami speaking municipalities and a control group. Are early outcome measures influenced by ethnicity?

Level of selected toxic elements in meat, liver, tallow and bone marrow of young semi-domesticated reindeer (Rangifer tarandus tarandus L.) from Northern Norway

Bachelor studies for nurses organised in rural contexts – a tool for improving the health care services in circumpolar region?

Preterm birth in the Inuit and First Nations populations of Québec, Canada, 1981–2008

Physical activity and fitness in 8-year-old overweight and normal weight children and their parents

Health consumption in Sami speaking municipalities and a control group with regard to medical imaging

Occurrence of pancreatic, biliary tract, and gallbladder cancers in Alaska Native people, 1973–2007

Gender differences in comorbidity of conduct disorder among adolescents in Northern Finland

Oral health in a First Nations and a non-Aboriginal population in Manitoba

Dietary quality and adequacy among Aboriginal alcohol consumers in the Northwest Territories, Canada

Design and methods in a survey of living conditions in the Arctic – the SLiCA study

Factors related to fruit, vegetable and traditional food consumption which may affect health among Alaska Native People in Western Alaska

Metabolic profile in two physically active Inuit groups consuming either a western or a traditional Inuit diet

Heart rate is associated with markers of fatty acid desaturation: the GOCADAN study

A longitudinal study of the effect of Antarctic residence on energy dynamics and aerobic fitness

Traditional food consumption behaviour and concern with environmental contaminants among Cree schoolchildren of the Mushkegowuk territory

The impact of Action Schools! BC on the health of Aboriginal children and youth living in rural and remote communities in British Columbia

Level and temporal trend of perfluoroalkyl acids in Greenlandic Inuit

Inuit women's attitudes and experiences towards cervical cancer and prevention strategies in Nunavik, Quebec

Level of selected nutrients in meat, liver, tallow and bone marrow from semi-domesticated reindeer (Rangifer t. tarandus L.)

Sami-speaking municipalities and a control group's access to somatic specialist health care (SHC): a retrospective study on general practitioners’ referrals

No association between temperature and deaths from cardiovascular and cerebrovascular diseases during the cold season in Astana, Kazakhstan – the second coldest capital in the world

Against the stream: relevance of gluconeogenesis from fatty acids for natives of the arctic regions

Demographic and contextual factors associated with inhalant use among youth in rural Alaska

Addressing challenges in participatory research partnerships in the North: opening a conversation

Community-based Participatory Process – Climate Change and Health Adaptation Program for Northern First Nations and Inuit in Canada

Being useful: achieving indigenous youth involvement in a community-based participatory research project in Alaska

Challenges created by data dissemination and access restrictions when attempting to address community concerns: individual privacy versus public wellbeing

Youth researching youth: benefits, limitations and ethical considerations within a participatory research process

Knowledge translation in Arctic environmental health

The best of two worlds: how the Greenland Board of Nutrition has handled conflicting evidence about diet and health

Dietary recommendations regarding pilot whale meat and blubber in the Faroe Islands

From science to action and from action to science: the Nunavik Trichinellosis Prevention Program

Lead exposure in Nunavik: from research to action

Dietary exposure to persistent organic pollutants and metals among Inuit and Chukchi in Russian Arctic Chukotka

Translational research to reduce trans-fat intakes in Northern Québec (Nunavik) Inuit communities: a success story?

Vitamin D deficiency among northern Native Peoples: a real or apparent problem?

The international biological program/human adaptability studies among the Skolt Sami in Finland (1966–1970)

Reply to W.B. Grant ‘Re: Vitamin D deficiency among northern Native Peoples’

Re: Vitamin D deficiency among northern Native Peoples

Volume 70, 2011

Volume 69, 2010

Volume 68, 2009

Volume 67, 2008

Volume 66, 2007

Volume 65, 2006

Volume 64, 2005

Volume 63, 2004

Volume 62, 2003

Volume 61, 2002

Volume 60, 2001

Against the stream: relevance of gluconeogenesis from fatty acids for natives of the arctic regions

Content Provider	Taylor & Francis Online
Author	Figueiredo, Luís F. De Schuster, Stefan Kaleta, Christoph
Abstract	Background. The question whether even-chain fatty acids can be converted into glucose has a long-standing tradition in biochemistry. Since the glyoxylate shunt is absent from mammals, the question has been considered to be solved. It is of particular relevance for understanding the metabolic state of natives of the arctic regions due to the very high fat content of their traditional diet only containing negligible amounts of carbohydrates. Methods & Results. Using an in silico approach, we discovered several hitherto unknown routes in human metabolism that allow the conversion of even-chain fatty acids into carbohydrates in humans. These pathways proceed via ketogenesis over the intermediate of acetone and produce the gluconeogenic precursor pyruvate. While these pathways can make a contribution to glucose production during times of limited carbohydrate supply, we found that their capacity might be limited due to a high demand in reducing equivalents in acetone degradation. Considering the traditional diet of natives of the arctic regions, the detected pathways are not only important in order to improve carbohydrate supply, but moreover reduce the amount of protein that needs to be used for gluconeogenesis. Conclusion. In summary, our study sheds new light on our understanding of the metabolic state of natives from the arctic regions on their traditional diet. Moreover, they provide an avenue for new analyses that can reveal how humans have adapted metabolically to a practically carbohydrate-free diet.
File Format	PDF HTM / HTML
ISSN	22423982
DOI	10.3402/ijch.v71i0.18436
Journal	International Journal of Circumpolar Health
Volume Number	71
Issue Number	1
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-05-03
Access Restriction	Open
Subject Keyword	Carbohydrate-free diet Gluconeogenesis Inuit diet Ketogenesis Even-chain fatty acids
Content Type	Text
Resource Type	Article
Subject	Health (social science) Public Health, Environmental and Occupational Health Epidemiology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in