NDLI: Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats

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Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats

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Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats

Content Provider	Taylor & Francis Online
Author	You, Yanghee Kim, Kyungmi Park, Jeongjin Jun, Woojin Kim, Ji Hye Kim, Ok-Kyung Lee, Yoo-Hyun Choi, Kyung-Chul Yoon, Ho-Geun Lee, Jeongmin
Abstract	BackgroundEven though Curcuma longa L. possesses various biological activities, it has strong flavor and taste, which decrease consumer palatability and limit industrial applications in food.ObjectiveThe present study investigates the effects of C. longa L. fermented with Aspergillus oryzae supplementation in 60% high-fat diet-induced obese rats measured by the activation of adipogenesis and lipolysis.DesignRats were divided into four groups (n=6 per group) after 1 week of acclimatization: a normal diet group comprised rats fed the AIN76A rodent diet; a high-fat diet-induced obese group with rats fed a 60% high-fat diet; a Garcinia cambogia treated group (positive control) with rats fed a 60% high-fat diet with G. cambogia 500 g/kg body weight (b.w.)/day; and an fermented C. longa L. 50% ethanolic extract treated group (FCE50) with rats fed a 60% high-fat diet with FCE50 500 g/kg b.w./day. Each group received the appropriate vehicle or sample daily by gastric intubation for 12 weeks.ResultsWe found that FCE50 administration suppressed b.w. gain and reduced white adipose tissue weight, serum triglyceride (TG), and cholesterol in high-fat diet-induced obese rats. These results can be associated with the suppression of adipocyte differentiation and lipogenesis with a decrease in the mRNA expressions of fatty acid synthase, acetyl-CoA carboxylase, adipocyte protein 2, and lipoprotein lipase induced by FCE50 administration. In addition, FCE50 increased lipolysis and β-oxidation by up-regulating the expression of lipases such as adipose triglyceride lipase, hormone-sensitive lipase, adiponectin, and AMP-activated protein kinase.ConclusionsThese results suggest that FCE50 can be a candidate for the prevention of obesity via suppressing adipogenesis and promoting lipolysis.
File Format	PDF HTM / HTML
ISSN	16546628 1654661X
DOI	10.3402/fnr.v60.30428
Journal	Food & Nutrition Research
Volume Number	60
Issue Number	1
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-01-27
Access Restriction	Open
Subject Keyword	Curcuma longa High-fat diet Adipogenesis Lipolysis Anti-obesity
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Public Health, Environmental and Occupational Health Food Science

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