NDLI: Beneficial effect of medicinal plants on the contractility of post-hypoxic isolated guinea pig atria – Potential implications for the treatment of ischemic

Content Provider	Taylor & Francis Online
Author	Pawirodihardjo, Jennifer Magali, Indira Oedairadjsingh, Krishan Stender, Karin Mans, Dennis R. A. Bipat, Robbert Wangsawirana, Angelique Soekhoe, Rubaina Toelsie, Jerry R.
Abstract	Context Ischemic–reperfusion injury is accompanied by a decreased contractility of the myocardium. Positive-inotropic agents have proven useful for treating this condition but may exert serious side-effects.Objective In this study, aqueous preparations from Abelmoschus esculentus L. Moench (Malvaceae), Annona muricata L. (Annonaceae), Bixa orellana L. (Bixaceae), Cecropia peltata L. (Moraceae), Erythrina fusca Lour. (Fabaceae), Psidium guajava L. (Myrtaceae) and Terminalia catappa L. (Combretaceae) were evaluated for their ability to improve the decreased contractility of isolated guinea pig atria after hypoxic stress.Materials and methods Guinea pig atria isolated in Ringer-Locke buffer gassed with 100% O2 at 30 °C were exposed for 5 min to hypoxia, then allowed to recover in oxygenated buffer alone or containing a single plant extract (0.001–1 mg/mL). The contractility (g/s) and beating frequency (beats/min), as well as troponin C contents of the bathing solution (ng/mL), were determined and expressed as means ± SDs.Results The extracts of A. muricata, B. orellana, C. peltata and T. catappa caused an increase in the contractility compared to untreated atria of 340 ± 102%, 151 ± 13%, 141 ± 14% and 238 ± 44%, respectively. However, the latter two preparations increased the troponin C contents of the bathing solution to 36 ± 11 and 69 ± 33, compared to the value of 11 ± 3 ng/mL found with untreated atria.Conclusions Preparations from A. muricata and B. orellana may possess positive-inotropic properties which may improve the contractility of the post-hypoxic myocardium. Studies to assess their usefulness in ischemic–reperfusion injury are warranted.
Starting Page	1483
Ending Page	1489
Page Count	7
File Format	PDF HTM / HTML
ISSN	13880209 17445116
DOI	10.3109/13880209.2015.1107103
Journal	Pharmaceutical Biology
Volume Number	54
Issue Number	8
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-01-05
Access Restriction	Open
Subject Keyword	Hypoxia Troponin C Positive-inotropism
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science

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