NDLI: Ligularia fischeri extract attenuates liver damage induced by chronic alcohol intake

Content Provider	Taylor & Francis Online
Author	Kim, Dongyeop Lee, Seon-Ho Han, Gi Dong Kim, Gyeong-Woo
Abstract	Context Ligularia fischeri (Ledebour) Turcz. (Compositae) has been used as a leafy vegetable and in traditional medicine to treat hepatic disorder in East Asia.Objective The present study explores the antioxidant activity of LF aqueous extract on EtOH-induced oxidative stress accompanied by hepatotoxicity both in vitro and in vivo.Materials and methods In vitro study using the mouse liver NCTC-1469 cell line was conducted to estimate the cytotoxicity as well as the inhibitory effect of LF extract against alcohol-treated cell damage. In vivo study used an alcohol-fed Wister rat model orally administered EtOH (3.95 g/kg of body weight/d) with or without LF extract (100 or 200 mg/kg body weight) for 6 weeks. Serum and liver tissue were collected to evaluate hepatic injury and antioxidant-related enzyme activity.Results The EC50 value for the DPPH radical scavenging capacity of LF extract was 451.5 μg/mL, whereas the IC50 value of LF extract in terms of EtOH-induced reactive oxygen species (ROS) generation was 98.3 μg/mL without cell cytotoxicity. LF extract (200 mg/kg body weight) significantly reduced the triglyceride content of serum (33%) as well as hepatic lipid peroxidation (36%), whereas SOD activity was elevated three-fold. LF extract suppressed expression of CYP2E1 and TNF-α, and attenuated alcohol-induced abnormal morphological changes.Discussion and conclusion LF extract attenuated liver damage induced by alcoholic oxidative stress through inhibition of ROS generation, down-regulation of CYP2E1, and activation of hepatic antioxidative enzymes. Homeostasis of the antioxidative defence system in the liver by LF extract mitigated hepatic disorder following chronic alcohol intake.
Starting Page	1465
Ending Page	1473
Page Count	9
File Format	PDF HTM / HTML
ISSN	13880209 17445116
DOI	10.3109/13880209.2015.1104701
Journal	Pharmaceutical Biology
Volume Number	54
Issue Number	8
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-01-22
Access Restriction	Open
Subject Keyword	Alcohol-fed rat model Alcoholic liver disease Antioxidative enzyme Hepatoprotection Reactive oxygen species
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science

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