NDLI: Prussian blue nanoparticles as nanocargoes for delivering DNA drugs to cancer cells

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Prussian blue nanoparticles as nanocargoes for delivering DNA drugs to cancer cells

Content Provider	Taylor & Francis Online
Author	Wang, Shao-Jen Chen, Chun-Sheng Chen, Lin-Chi
Abstract	We studied the use of Prussian blue nanoparticles (PBNPs) as novel nanocarriers for sending DNA drugs into cancer cells. 11-mercaptoundecanoic acid (MUA) was used to functionalize the surfaces of PBNPs (nanocubes with an average dimension of 75 nm) for subsequent covalent grafting of a 33-mer DNA drug with a FAM reporter at the 3′ end. The PBNPs synthesis and DNA drug conjugation were characterized by transmission electron microscopy (TEM) and Fourier-transform infrared absorption (FTIR), respectively. The drug was a decoy oligodeoxynucleotide (dODN) that inhibits the signal transducer and activator of transcription 3 (STAT3). The DNA–PBNPs drug (dODN@MUA–PBNPs) was delivered into human prostate carcinoma 22rv1 cells by endocytosis in vitro as confirmed by confocal fluorescence microscopy. MTT cell viability assays were carried out to assess the effect of the DNA–PBNPs drug. The results showed that the dODN molecules were successfully conjugated to the MUA modified PBNPs via amide and/or disulfide bond formation and could thus be successfully delivered into the cancer cells. The control experiments showed that the unconjugated dODN molecules were not able to enter the cancer cells no matter whether non-functionalized PBNPs were present or not. It was also found that the DNA-PBNPs drugs were internalized and then distributed homogeneously throughout the cell, including cytoplasmic and nucleic regions, after endocytosis. The cancer cell-killing ability increased with the amount of dODN conjugated on PBNPs and the dosage of DNA–PBNPs drug internalized.
File Format	PDF HTM / HTML
ISSN	14686996 18785514
DOI	10.1088/1468-6996/14/4/044405
Journal	Science and Technology of Advanced Materials
Volume Number	14
Issue Number	4
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-08-06
Access Restriction	Open
Subject Keyword	10.01 10.10 30.1 Prussian blue nanoparticles (PBNPs) Drug delivery system (DDS) 11-mercaptoundecanoic acid (MUA) Decoy oligodeoxynucleotide (dODN) Prostate cancer cell
Content Type	Text
Resource Type	Article
Subject	Materials Science

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