NDLI: YI 1.1 Aortic Impedance and Total Arterial Compliance from Regional Pulse Wave Velocities

Content Provider	Springer Nature : BioMed Central
Author	Bikia, Vasiliki Rovas, Georgios Pagoulatou, Stamatia Stergiopulos, Nikolaos
Abstract	Background In-vivo assessment of aortic characteristic impedance (Zao) and total arterial compliance (CT) has been hampered by the need for invasive methods to access simultaneous recordings of aortic pressure and flow, wall thickness, and cross-sectional area. In contrast, regional pulse wave velocity (PWV) measurements are noninvasive and clinically available. Given that PWV is strongly related to aortic stiffness (1), we assume that carotid-to-femoral PWV (cfPWV) and carotid-to-radial PWV (crPWV) may contain sufficient information to evaluate the elasticity of the ascending aorta. Concretely, here, we present a noninvasive regression method for estimating Zao and CT using cuf pressure, cfPWV, and crPWV. Methods Gradient Boosting is employed for predicting Zao, and CT. The regressors are trained/tested using a pool of virtual subjects (n = 4833) generated from a previously validated in-silico model (2). The cross validation is performed using a 10-fold cross-validation (3).The population used has been previously generated (4) and reflects a wide range of hemodynamical properties and states. Results Predictions had a high accuracy (Figure) achieving a normalized-RMSE equal to 6.24 ± 1.19% (r = 0.85, p < 0.001) for Zao, and 4.38 ± 0.36% (r = 0.97, p < 0.001) for CT, respectively. High errors were reported for high values of Zao due to the limited amount of similar data. Conclusion The proposed approach constitutes a step forward to noninvasive screening of elastic vascular properties in human by exploiting easily obtained measurements. This study could introduce a valuable tool for assessing aortic stiffness reducing the cost and the complexity of the required measuring techniques. Clinical evaluation is required to validate the method in-vivo.
Related Links	https://arteryresearch.biomedcentral.com/counter/pdf/10.2991/artres.k.201209.001.pdf
Ending Page	S1
Page Count	1
Starting Page	S1
File Format	HTM / HTML
ISSN	18764401
DOI	10.2991/artres.k.201209.001
Journal	Artery Research
Issue Number	1
Volume Number	26
Language	English
Publisher	BioMed Central
Publisher Date	2020-12-31
Access Restriction	Open
Subject Keyword	Medicine Public Health Medicine/Public Health
Content Type	Text
Resource Type	Synopsis
Subject	Physiology (medical) Physiology
Journal Impact Factor	0.9/2023
5-Year Journal Impact Factor	0.7/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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