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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Boukelmoune, Nabila Chiu, Gabriel S. Kavelaars, Annemieke Heijnen, Cobi J. |
| Abstract | Mesenchymal stem cells (MSCs) transfer healthy mitochondria to damaged acceptor cells via actin-based intercellular structures. In this study, we tested the hypothesis that MSCs transfer mitochondria to neural stem cells (NSCs) to protect NSCs against the neurotoxic effects of cisplatin treatment. Our results show that MSCs donate mitochondria to NSCs damaged in vitro by cisplatin. Transfer of healthy MSC-derived mitochondria decreases cisplatin-induced NSC death. Moreover, mitochondrial transfer from MSCs to NSCs reverses the cisplatin-induced decrease in mitochondrial membrane potential. Blocking the formation of actin-based intercellular structures inhibited the transfer of mitochondria to NSCs and abrogated the positive effects of MSCs on NSC survival. Conversely, overexpression of the mitochondrial motor protein Rho-GTPase 1 (Miro1) in MSCs increased mitochondrial transfer and further improved survival of cisplatin-treated NSCs.In vivo, MSC administration prevented the loss of DCX+ neural progenitor cells in the subventricular zone and hippocampal dentate gyrus which occurs as a result of cisplatin treatment. We propose mitochondrial transfer as one of the mechanisms via which MSCs exert their therapeutic regenerative effects after cisplatin treatment. |
| Related Links | https://actaneurocomms.biomedcentral.com/counter/pdf/10.1186/s40478-018-0644-8.pdf |
| Ending Page | 13 |
| Page Count | 13 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 20515960 |
| DOI | 10.1186/s40478-018-0644-8 |
| Journal | Acta Neuropathologica Communications |
| Issue Number | 1 |
| Volume Number | 6 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2018-12-12 |
| Access Restriction | Open |
| Subject Keyword | Neurosciences Pathology Neurology Mesenchymal stem cells Neuronal stem cells Mitochondrial transfer Cisplatin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pathology and Forensic Medicine Neurology (clinical) Cellular and Molecular Neuroscience |
| Journal Impact Factor | 6.2/2023 |
| 5-Year Journal Impact Factor | 6.8/2023 |
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