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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Feng, Zhen Hou, Yan Yu, Chang Li, Ting Fu, Haoyang Lv, Feng Li, Ping |
| Abstract | Perioperative neurocognitive disorder (PND) is a common neurological complication after surgery/anesthesia in elderly patients that affect postoperative outcome and long-term quality of life, which increases the cost of family and social resources. The pathological mechanism of PND is complex and not fully understood, and the methods of prevention and treatment of PND are very limited, so it is particularly important to analyze the mechanism of PND. Research indicates that mitochondrial dysfunction is pivotal in the initiation and progression of PND, although the precise mechanisms remain elusive and could involve disrupted mitophagy. We reviewed recent studies on the link between mitophagy and PND, highlighting the role of key proteins in abnormal mitophagy and discussing therapeutic strategies aimed at mitophagy regulation. This provides insights into the mechanisms underlying PND and potential therapeutic targets. |
| Related Links | https://eurjmedres.biomedcentral.com/counter/pdf/10.1186/s40001-025-02400-1.pdf |
| Ending Page | 13 |
| Page Count | 13 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s40001-025-02400-1 |
| Journal | European Journal of Medical Research |
| Issue Number | 1 |
| Volume Number | 30 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2025-04-11 |
| Access Restriction | Open |
| Subject Keyword | Medicine Public Health Infectious Diseases Internal Medicine Surgery Oncology Biomedicine Mitophagy Perioperative neurocognitive disorder NLRP3 inflammasome Pyroptosis Medicine/Public Health |
| Content Type | Text |
| Resource Type | Review |
| Subject | Medicine |
| Journal Impact Factor | 2.8/2023 |
| 5-Year Journal Impact Factor | 2.9/2023 |
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