NDLI: Molecular epidemiology, microbiological features and infection control strategies for carbapenem-resistant Acinetobacter baumannii in a German burn and plastic surgery center (2020

Content Provider	Springer Nature : BioMed Central
Author	Vital, Marius Woltemate, Sabrina Schlüter, Dirk Krezdorn, Nicco Dieck, Thorben Dastagir, Khaled Bange, Franz-Christoph Ebadi, Ella Vogt, Peter M. Knegendorf, Leonard Baier, Claas
Abstract	Background Carbapenem-resistant Acinetobacter baumannii (CRAB) frequently causes both healthcare-associated infections and nosocomial outbreaks in burn medicine/plastic surgery and beyond. Owing to the high antibiotic resistance, infections are difficult to treat, and patient outcomes are often compromised. The environmental persistence capability of CRAB favors its transmission in hospitals. A comprehensive analysis and understanding of CRAB epidemiology and microbiology are essential for guiding management. Methods A three-year retrospective cohort study (2020–2022) was conducted in a German tertiary burn and plastic surgery center. In addition to epidemiological analyses, microbiological and molecular techniques, including whole-genome sequencing, were applied for the comprehensive examination of isolates from CRAB-positive patients. Results During the study period, eight CRAB cases were found, corresponding to an overall incidence of 0.2 CRAB cases per 100 cases and an incidence density of 0.35 CRAB cases per 1000 patient-days. Six cases (75%) were treated in the burn intensive care unit, and four cases (50%) acquired CRAB in the hospital. Molecular analyses comprising 74 isolates supported the epidemiologic assumption that hospital acquisitions occurred within two separate clusters. In one of these clusters, environmental CRAB contamination of anesthesia equipment may have enabled transmission. Furthermore, molecular diversity of CRAB isolates within patients was observed. Conclusions CRAB can pose a challenge in terms of infection prevention and control, especially if cases are clustered in time and space on a ward. Our study demonstrates that high-resolution phylogenetic analysis of several bacterial isolates from single patients can greatly aid in understanding transmission chains and helps to take precision control measures.
Related Links	https://aricjournal.biomedcentral.com/counter/pdf/10.1186/s13756-024-01459-5.pdf
Ending Page	11
Page Count	11
Starting Page	1
File Format	HTM / HTML
ISSN	20472994
DOI	10.1186/s13756-024-01459-5
Journal	Antimicrobial Resistance & Infection Control
Issue Number	1
Volume Number	13
Language	English
Publisher	BioMed Central
Publisher Date	2024-09-06
Access Restriction	Open
Subject Keyword	Medical Microbiology Drug Resistance Infectious Diseases Acinetobacter baumannii Carbapenem Resistance Infection prevention and control Epidemiology Whole-genome sequencing Microbiology
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Infectious Diseases Microbiology (medical) Pharmacology (medical)
Journal Impact Factor	4.8/2023
5-Year Journal Impact Factor	5.8/2023

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