NDLI: Chlorhexidine-coated surgical gloves influence the bacterial flora of hands over a period of 3 hours

Content Provider	Springer Nature : BioMed Central
Author	Suchomel, Miranda Brillmann, Markus Assadian, Ojan Ousey, Karen J. Presterl, Elisabeth
Abstract	Background The risk of SSI increases in the presence of foreign materials and may be caused by organisms with low pathogenicity, such as skin flora derived from hands of surgical team members in the event of a glove breach. Previously, we were able to demonstrate that a novel antimicrobial surgical glove coated chlorhexidine-digluconate as the active ingredient on its inner surface was able to suppress surgeons’ hand flora during operative procedures by a magnitude of 1.7 log10 cfu/mL. Because of the clinical design of that study, we were not able to measure the full magnitude of the possible antibacterial suppression effect of antimicrobial gloves over a full 3 h period. Methods The experimental procedure followed the method for assessment of the 3-h effects of a surgical hand rub’s efficacy to reduce the release of hand flora as described in the European Norm EN 12791. Healthy volunteers tested either an antimicrobial surgical glove or non-antimicrobial surgical latex gloves in a standardized laboratory-based experiment over a wear time of 3 h. Results Wearing antimicrobial surgical glove after a surgical hand rub with 60% (v/v) n-propanol resulted in the highest 3-h reduction factor of 2.67 log10. Non-antimicrobial surgical gloves demonstrated significantly lower (p ≤ 0.01) 3-h reduction factors at 1.96 log10 and 1.68 log10, respectively. Antibacterial surgical gloves are able to maintain a sustainable bacterial reduction on finger tips in a magnitude of almost 3 log10 (log10 2.67 cfu) over 3 h wear time. Conclusion It was demonstrated that wear of an antibacterial surgical glove coated with chlorhexidine-digluconate is able to suppress resident hand flora significantly over a period of 3-h.
Related Links	https://aricjournal.biomedcentral.com/counter/pdf/10.1186/s13756-018-0395-0.pdf
Ending Page	5
Page Count	5
Starting Page	1
File Format	HTM / HTML
ISSN	20472994
DOI	10.1186/s13756-018-0395-0
Journal	Antimicrobial Resistance & Infection Control
Issue Number	1
Volume Number	7
Language	English
Publisher	BioMed Central
Publisher Date	2018-09-06
Access Restriction	Open
Subject Keyword	Medical Microbiology Drug Resistance Infectious Diseases Surgical glove Perforation Bacterial migration Antimicrobial efficacy Surgical site infection Bacterial skin flora Antimicrobial glove Chlorhexidine Antiseptic
Content Type	Text
Resource Type	Article
Subject	Public Health, Environmental and Occupational Health Infectious Diseases Microbiology (medical) Pharmacology (medical)
Journal Impact Factor	4.8/2023
5-Year Journal Impact Factor	5.8/2023

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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