| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Fernández-Ponce, Cecilia Navarro Quiroz, Roberto Díaz Perez, Anderson Aroca Martinez, Gustavo Cadena Bonfanti, Andrés Acosta Hoyos, Antonio Gómez Escorcia, Lorena Hernández Agudelo, Sandra Orozco Sánchez, Christian Villarreal Camacho, José Atencio Ibarra, Linda Consuegra Machado, Jose Espinoza Garavito, Alberto García-Cózar, Francisco Navarro Quiroz, Elkin |
| Abstract | Background In this review, we were interested to identify the wide universe of enzymes associated with epigenetic modifications, whose gene expression is regulated by miRNAs with a high relative abundance in Crohn's disease (CD) affected tissues, with the aim to determine their impact in the pathogenesis and evolution of the disease. Methods We used HMDD and Bibliometrix R-package in order to identify the miRNAs overexpressed in CD. The identified enzymes associated with epigenetic mechanisms and post-translational modifications, regulated by miRNAs upregulated in CD, were analyzed using String v11 database. Results We found 190 miRNAs with great abundance in patients with CD, of which 26 miRNAs regulate the gene expression of enzymes known to catalyze epigenetic modifications involved in essentials pathophysiological processes, such as chromatin architecture reorganization, immune response regulation including CD4+ T cells polarization, integrity of gut mucosa, gut microbiota composition and tumorigenesis. Conclusion The integrated analysis of miRNAs with a high relative abundance in patients with CD showed a combined and superimposed gene expression regulation of enzymes associated with relevant epigenetic mechanisms and that could explain, in part, the pathogenesis of CD. |
| Related Links | https://clinicalepigeneticsjournal.biomedcentral.com/counter/pdf/10.1186/s13148-021-01022-8.pdf |
| Ending Page | 11 |
| Page Count | 11 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 18687083 |
| DOI | 10.1186/s13148-021-01022-8 |
| Journal | Clinical Epigenetics |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2021-02-18 |
| Access Restriction | Open |
| Subject Keyword | Human Genetics Gene Function MicroRNA Crohn’s disease Epigenetic mechanisms Post-translational modifications T cells |
| Content Type | Text |
| Resource Type | Review |
| Subject | Molecular Biology Genetics (clinical) Developmental Biology Genetics |
| Journal Impact Factor | 4.8/2023 |
| 5-Year Journal Impact Factor | 5.8/2023 |
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