| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Pischedda, Sara O’Connor, Daniel Fairfax, Benjamin P. Salas, Antonio Martinon-Torres, Federico Pollard, Andrew J. Trück, Johannes |
| Abstract | Background Pneumococcal infections are a major cause of morbidity and mortality in young children and immaturity of the immune system partly underlies poor vaccine responses seen in the young. Emerging evidence suggests a key role for epigenetics in the maturation and regulation of the immune system in health and disease. The study aimed to investigate epigenetic changes in early life and to understand the relationship between the epigenome and antigen-specific antibody responses to pneumococcal vaccination. Methods The epigenetic profiles from 24 healthy children were analyzed at 12 months prior to a booster dose of the 13-valent pneumococcal conjugate vaccine (PCV-13), and at 24 months of age, using the Illumina Methylation 450 K assay and assessed for differences over time and between high and low vaccine responders. Results Our analysis revealed 721 significantly differentially methylated positions between 12 and 24 months (FDR < 0.01), with significant enrichment in pathways involved in the regulation of cell–cell adhesion and T cell activation. Comparing high and low vaccine responders, we identified differentially methylated CpG sites (P value < 0.01) associated with HLA-DPB1 and IL6. Conclusion These data imply that epigenetic changes that occur during early childhood may be associated with antigen-specific antibody responses to pneumococcal vaccines. |
| Related Links | https://clinicalepigeneticsjournal.biomedcentral.com/counter/pdf/10.1186/s13148-021-01012-w.pdf |
| Ending Page | 12 |
| Page Count | 12 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 18687083 |
| DOI | 10.1186/s13148-021-01012-w |
| Journal | Clinical Epigenetics |
| Issue Number | 1 |
| Volume Number | 13 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2021-02-04 |
| Access Restriction | Open |
| Subject Keyword | Human Genetics Gene Function Pneumococcal vaccination Immune system Childhood Vaccine response Epigenetics DNA methylation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Biology Genetics (clinical) Developmental Biology Genetics |
| Journal Impact Factor | 4.8/2023 |
| 5-Year Journal Impact Factor | 5.8/2023 |
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