NDLI: Centriolin interacts with HectD1 in a cell cycle dependent manner

Content Provider	Springer Nature : BioMed Central
Author	Salas, Jesus Garcia, Alexander Zora, Vancy Dornbush, Sean Mousa-Ibrahim, Fady Fogg, Hanna Gromley, Zeynep Gromley, Adam
Abstract	Objective The centrosome is universally recognized as the microtubule organizing center of animal cells, but emerging evidence suggests that it has other important functions including primary cilia formation, DNA damage checkpoints, and cell cycle progression. Despite this, the role of individual components of the centrosome remains unclear. Previous studies suggest that one component, centriolin, has an important function in cytokinesis and cell cycle progression, although its exact role in these processes is not known. To determine how centriolin influences the progression through the cell cycle, we sought to identify interacting partners that may be involved in regulating its function. Results This study provides evidence that the ubiquitin E3 ligase HectD1 binds to centriolin and that this association likely accounts for our observation that HectD1 co-localizes with centriolin at the centrosome during mitosis. In addition to its centrosomal localization, we also show that the expression of HectD1 fluctuates throughout the cell cycle, with the highest levels during mitosis, coinciding with a marked reduction in centriolin expression. We propose that the interaction between HectD1 and centriolin may be necessary for normal cell cycle progression and we speculate that this function may involve HectD1-mediated degradation of centriolin.
Related Links	https://bmcresnotes.biomedcentral.com/counter/pdf/10.1186/s13104-023-06670-y.pdf
Ending Page	6
Page Count	6
Starting Page	1
File Format	HTM / HTML
ISSN	17560500
DOI	10.1186/s13104-023-06670-y
Journal	BMC Research Notes
Issue Number	1
Volume Number	16
Language	English
Publisher	BioMed Central
Publisher Date	2023-12-19
Access Restriction	Open
Subject Keyword	Biomedicine Medicine Public Health Life Sciences HECTD1 Centriolin Centrosome Mitosis Medicine/Public Health
Content Type	Text
Resource Type	Article
Subject	Biochemistry, Genetics and Molecular Biology Medicine
Journal Impact Factor	1.6/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

CRISPR/Cas9 genome editing system confirms centriolin’s role in cytokinesis

IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis

Aurora A kinase (AURKA) in normal and pathological cell division

Mitosis: wisdom, knowledge, and information

Centrioles: active players or passengers during mitosis?

Cell cycle-dependent localization of CHK2 at centrosomes during mitosis

53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis.

Show me your license, please: deregulation of centriole duplication mechanisms that promote amplification

Integrin-linked kinase regulates senescence in an Rb-dependent manner in cancer cell lines

Centriolin interacts with HectD1 in a cell cycle dependent manner

Similar Documents

CRISPR/Cas9 genome editing system confirms centriolin’s role in cytokinesis

IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis

Aurora A kinase (AURKA) in normal and pathological cell division

Mitosis: wisdom, knowledge, and information

Centrioles: active players or passengers during mitosis?

Cell cycle-dependent localization of CHK2 at centrosomes during mitosis

53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis.

Show me your license, please: deregulation of centriole duplication mechanisms that promote amplification

Integrin-linked kinase regulates senescence in an Rb-dependent manner in cancer cell lines

Centriolin interacts with HectD1 in a cell cycle dependent manner