NDLI: Vasoresponsiveness in patients with heart failure (VASOR): protocol for a prospective observational study

Content Provider	Springer Nature : BioMed Central
Author	van Vessem, Marieke E. Beeres, Saskia L. M. A. de Wilde, Rob B. P. de Vries, René Berendsen, Remco R. de Jonge, Evert Danser, A. H. Jan Klautz, Robert J. M. Schalij, Martin J. Palmen, Meindert
Abstract	Background Vasoplegia is a severe complication which may occur after cardiac surgery, particularly in patients with heart failure. It is a result of activation of vasodilator pathways, inactivation of vasoconstrictor pathways and the resistance to vasopressors. However, the precise etiology remains unclear. The aim of the Vasoresponsiveness in patients with heart failure (VASOR) study is to objectify and characterize the altered vasoresponsiveness in patients with heart failure, before, during and after heart failure surgery and to identify the etiological factors involved. Methods This is a prospective, observational study conducted at Leiden University Medical Center. Patients with and patients without heart failure undergoing cardiac surgery on cardiopulmonary bypass are enrolled. The study is divided in two inclusion phases. During phase 1, 18 patients with and 18 patients without heart failure are enrolled. The vascular reactivity in response to a vasoconstrictor (phenylephrine) and a vasodilator (nitroglycerin) is assessed in vivo on different timepoints. The response to phenylephrine is assessed on t1 (before induction), t2 (before induction, after start of cardiotropic drugs and/or vasopressors), t3 (after induction), t4 (15 min after cessation of cardiopulmonary bypass) and t5 (1 day post-operatively). The response to nitroglycerin is assessed on t1 and t5. Furthermore, a sample of pre-pericardial fat tissue, containing resistance arteries, is collected intraoperatively. The ex vivo vascular reactivity is assessed by constructing concentrations response curves to various vasoactive substances using isolated resistance arteries. Next, expression of signaling proteins and receptors is assessed using immunohistochemistry and mRNA analysis. Furthermore, the groups are compared with respect to levels of organic compounds that can influence the cardiovascular system (e.g. copeptin, (nor)epinephrine, ANP, BNP, NTproBNP, angiotensin II, cortisol, aldosterone, renin and VMA levels). During inclusion phase 2, only the ex vivo vascular reactivity test is performed in patients with (N = 12) and without heart failure (N = 12). Discussion Understanding the difference in vascular responsiveness between patients with and without heart failure in detail, might yield therapeutic options or development of preventive strategies for vasoplegia, leading to safer surgical interventions and improvement in outcome. Trial registration The Netherlands Trial Register (NTR), NTR5647. Registered 26 January 2016.
Related Links	https://cardiothoracicsurgery.biomedcentral.com/counter/pdf/10.1186/s13019-019-1014-8.pdf
Ending Page	9
Page Count	9
Starting Page	1
File Format	HTM / HTML
ISSN	17498090
DOI	10.1186/s13019-019-1014-8
Journal	Journal of Cardiothoracic Surgery
Issue Number	1
Volume Number	14
Language	English
Publisher	BioMed Central
Publisher Date	2019-11-21
Access Restriction	Open
Subject Keyword	Cardiac Surgery Thoracic Surgery Vasoplegia Vasoplegic syndrome Vasodilatory shock Heart failure surgery Vasoresponsiveness Vasoreactivity
Content Type	Text
Resource Type	Article
Subject	Surgery Cardiology and Cardiovascular Medicine Pulmonary and Respiratory Medicine
Journal Impact Factor	1.5/2023
5-Year Journal Impact Factor	1.6/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The additional use of methylene blue has a decatecholaminisation effect on cardiac vasoplegic syndrome after cardiac surgery

Comparison of preoperative trans-thoracic echocardiography with intraoperative findings in patients with congenital heart disease undergoing surgery: a prospective observational study

A case report of primary cardiac myxofibrosarcoma presenting with severe congestive heart failure

Effects of thoracic epidural analgesia on plasma cAMP and cGMP levels in patients with heart failure

Diagnostic and prognostic value of microRNA423-5p in patients with heart failure

Optimal utilization of mechanical circulatory support and transplant resources in the comprehensive treatment of terminal heart failure

Association of postoperative delirium with hypotension in critically ill patients after cardiac surgery: a prospective observational study

Successful heart transplantation as third cardiac operation in a 12 year-old Marfan patient

Effects of neuromuscular electrostimulation in patients with heart failure admitted to ward

Vasoresponsiveness in patients with heart failure (VASOR): protocol for a prospective observational study

Similar Documents

The additional use of methylene blue has a decatecholaminisation effect on cardiac vasoplegic syndrome after cardiac surgery

Comparison of preoperative trans-thoracic echocardiography with intraoperative findings in patients with congenital heart disease undergoing surgery: a prospective observational study

A case report of primary cardiac myxofibrosarcoma presenting with severe congestive heart failure

Effects of thoracic epidural analgesia on plasma cAMP and cGMP levels in patients with heart failure

Diagnostic and prognostic value of microRNA423-5p in patients with heart failure

Optimal utilization of mechanical circulatory support and transplant resources in the comprehensive treatment of terminal heart failure

Association of postoperative delirium with hypotension in critically ill patients after cardiac surgery: a prospective observational study

Successful heart transplantation as third cardiac operation in a 12 year-old Marfan patient

Effects of neuromuscular electrostimulation in patients with heart failure admitted to ward

Vasoresponsiveness in patients with heart failure (VASOR): protocol for a prospective observational study