NDLI: Evaluation of a hybrid automatic planning solution for rectal cancer

Content Provider	Springer Nature : BioMed Central
Author	Peng, Jiyou Yu, Lei Xia, Fan Zhang, Kang Zhang, Zhen Wang, Jiazhou Hu, Weigang
Abstract	Script-based planning and knowledge-based planning are two kinds of automatic planning solutions. Hybrid automatic planning may integrate the advantages of both solutions and provide a more robust automatic planning solution in the clinic. In this study, we evaluated and compared a commercially available hybrid planning solution with manual planning and script-based planning. In total, 51 rectal cancer patients in our institution were enrolled in this study. Each patient generated 7 plans: one clinically accepted manual plan ( ${plan}_{manual}$ ), three script-based plans and three hybrid plans generated with the volumetric-modulated arc therapy technique and 3 different clinical goal settings: easy, moderate and hard ( ${plan}_{hybrid}^{easy}$ , ${plan}_{hybrid}^{moderate}$ , ${plan}_{hybrid}^{hard}$ , ${plan}_{script}^{easy}$ , ${plan}_{script}^{moderate}$ and ${plan}_{script}^{hard}$ ). Planning goals included planning target volume (PTV) Dmax, bladder Dmean and femur head Dmean. The PTV prescription was the same (50.00 Gy) for the 3 goal settings. The hard setting required a lower PTV Dmax and stricter organ at risk (OAR) dose, while the easy setting was the opposite. Plans were compared using dose metrics and plan quality metric (PQM) scores, including bladder D15 and D50, left and right femur head D25 and D40, PTV D2, D98, CI (conformity index) and HI (homogeneity index). Compared to manual planning, hybrid planning with all settings significantly reduced the OAR dose (p < 0.05, paired t-test or Wilcoxon signed rank test) for all dose-volume indices, except D25 of the left femur head. For script-based planning, ${plan}_{script}^{easy}$ significantly increased the OAR dose for the femur head and D2 and the PTV homogeneity index (p < 0.05, paired t-test or Wilcoxon signed rank test). Meanwhile, the maximum dose of the PTV was largely increased with hard script-based planning (D2 = 56.06 ± 7.57 Gy). For all three settings, the comparison of PQM between hybrid planning and script-based planning showed significant differences, except for D25 of the left femur head and PTV D2. The total PQM showed that hybrid planning could provide a better and more robust plan quality than script-based planning. The hybrid planning solution was manual-planning comparable for rectal cancer. Hybrid planning can provide a better and more robust plan quality than script-based planning.
Related Links	https://ro-journal.biomedcentral.com/counter/pdf/10.1186/s13014-022-02129-9.pdf
Ending Page	10
Page Count	10
Starting Page	1
File Format	HTM / HTML
DOI	10.1186/s13014-022-02129-9
Journal	Radiation Oncology
Issue Number	1
Volume Number	17
Language	English
Publisher	BioMed Central
Publisher Date	2022-10-13
Access Restriction	Open
Subject Keyword	Cancer Research Oncology Radiotherapy Imaging Radiology Automatic planning Hybrid planning Script-based planning Knowledge-based planning Rectal cancer
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Oncology
Journal Impact Factor	3.3/2023
5-Year Journal Impact Factor	3.6/2023

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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