NDLI: Antimicrobial treatment improves tryptophan metabolism and mood of patients with small intestinal bacterial overgrowth

Content Provider	Springer Nature : BioMed Central
Author	Chojnacki, Cezary Popławski, Tomasz Konrad, Paulina Fila, Michał Błasiak, Janusz Chojnacki, Jan
Abstract	Background Optimal composition of intestinal bacteria is an essential condition for good health. Excessive growth of these bacteria can cause various ailments. The aim of this study was to assess the mental state and gastrointestinal complaints of patients with small intestinal bacterial overgrowth (SIBO) in relation to tryptophan metabolism and rifaximin treatment. Methods 120 subjects, aged 23–61 years, were enrolled in the study, and divided into 3 groups, 40 individuals each: healthy subjects (Controls), patients with SIBO and chronic diarrhea (SIBO-D), and with chronic constipation (SIBO-C). The lactulose hydrogen breath test (LHBT) was performed to diagnose SIBO. The mental state of patients was assessed using the Hamilton Anxiety Rating Scale (HAM-A), and the Hamilton Depression Rating Scale (HAM-D). L-tryptophan (TRP) and its metabolites: 5-hydroxyindoleacetic acid (5-HIAA), kynurenine (KYN), xanthurenic acid (XA) and quinolinic acid (QA) were measured in urine by liquid-chromatography-tandem mass spectrometry and related to creatinine level. Patients with SIBO were recommended to take rifaximin for 10 days at daily dose 1200 mg, and this cycle was repeated in subsequent two months. Results Mild and moderate anxiety, as well as mild depression were diagnosed in all SIBO patients. Changes in TRP metabolism were also observed in these patients. Specifically, an increase in the activity of the serotonin pathway of TRP metabolism in the group SIBO-D was observed. The SIBO-C patients showed an increase in the concentration of KYN, XA and QA. 5-HIAA/TRP and KYN/TRP ratios significantly decreased in group SIBO-D, and KYN and QA levels decreased in group SIBO-C after treatment with rifaximin. The levels of anxiety and depression decreased in both groups. Conclusion Rifaximin treatment of SIBO patients ameliorated their mood disorders and gastrointestinal aliments underlined by changes in tryptophan metabolism. Trial registration Retrospectively registered (if applicable).
Related Links	https://nutritionandmetabolism.biomedcentral.com/counter/pdf/10.1186/s12986-022-00700-5.pdf
Ending Page	8
Page Count	8
Starting Page	1
File Format	HTM / HTML
ISSN	17437075
DOI	10.1186/s12986-022-00700-5
Journal	Nutrition & Metabolism
Issue Number	1
Volume Number	19
Language	English
Publisher	BioMed Central
Publisher Date	2022-09-27
Access Restriction	Open
Subject Keyword	Clinical Nutrition Metabolic Diseases Small intestinal bacterial overgrowth Tryptophan metabolism Anxiety Depression Rifaximin
Content Type	Text
Resource Type	Article
Subject	Medicine Endocrinology, Diabetes and Metabolism Nutrition and Dietetics
Journal Impact Factor	3.9/2023
5-Year Journal Impact Factor	4.3/2023

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Serotonin Pathway of Tryptophan Metabolism in Small Intestinal Bacterial Overgrowth—A Pilot Study with Patients Diagnosed with Lactulose Hydrogen Breath Test and Treated with Rifaximin

Altered Tryptophan Metabolism on the Kynurenine Pathway in Depressive Patients with Small Intestinal Bacterial Overgrowth

Rifaximin for small intestinal bacterial overgrowth in patients without irritable bowel syndrome

Preferential usage of rifaximin for the treatment of hydrogen-positive small intestinal bacterial overgrowth

Higher visceral to subcutaneous fat ratio is associated with small intestinal bacterial overgrowth.

Evidence of Prolonged Orocecal Transit Time and Small Intestinal Bacterial Overgrowth in Acromegalic Patients

Probiotics in prevention and treatment of obesity: a critical view

Association between Hypothyroidism and Small Intestinal Bacterial Overgrowth

Association between tryptophan concentrations and the risk of developing cardiovascular diseases: a systematic review and meta-analysis

Antimicrobial treatment improves tryptophan metabolism and mood of patients with small intestinal bacterial overgrowth

Similar Documents

Serotonin Pathway of Tryptophan Metabolism in Small Intestinal Bacterial Overgrowth—A Pilot Study with Patients Diagnosed with Lactulose Hydrogen Breath Test and Treated with Rifaximin

Altered Tryptophan Metabolism on the Kynurenine Pathway in Depressive Patients with Small Intestinal Bacterial Overgrowth

Rifaximin for small intestinal bacterial overgrowth in patients without irritable bowel syndrome

Preferential usage of rifaximin for the treatment of hydrogen-positive small intestinal bacterial overgrowth

Higher visceral to subcutaneous fat ratio is associated with small intestinal bacterial overgrowth.

Evidence of Prolonged Orocecal Transit Time and Small Intestinal Bacterial Overgrowth in Acromegalic Patients

Probiotics in prevention and treatment of obesity: a critical view

Association between Hypothyroidism and Small Intestinal Bacterial Overgrowth

Association between tryptophan concentrations and the risk of developing cardiovascular diseases: a systematic review and meta-analysis

Antimicrobial treatment improves tryptophan metabolism and mood of patients with small intestinal bacterial overgrowth