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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Dai, Li-Na Zhao, Yu-Ling Jiang, Lu Yan, Jun-Kai |
| Abstract | Background Parenteral nutrition (PN) may serve as a nutritional supportive therapy accompanied by oral medication, but the effect of PN on intestinal expression of drug metabolism-related genes remains unknown. Methods Twelve Bama piglets receiving PN for 14 days were used as in vivo model. Changes in intestinal drug metabolism-related genes were examined by proteomic analysis. Serum levels of fibroblast growth factor 19 (FGF19) were determined by ELISA, and the effect of FGF19 on the expression of drug metabolism-related genes was examined using murine ileum organoids. Results A total of 1063 differentially expressed proteins were identified in PN group. Of note, two drug transporters (Abcb1 and Abcc2) were significantly decreased in PN group, along with two glutathione-related drug-metabolizing enzymes, glutathione peroxidase (Gpx2) and glutathione S-transferase (Gsta1). Serum FGF19 levels were dramatically reduced in PN group. Treatment with recombinant FGF19 in vitro dose-dependently up-regulated the expression of Abcb1, Abcc2, Gpx2 and Gsta1 in organoids. Conclusion Our data indicated that intestinal drug metabolism-related genes were significantly dysregulated under PN, and some of the changed genes were attributed to gut-derived FGF19. |
| Related Links | https://nutritionandmetabolism.biomedcentral.com/counter/pdf/10.1186/s12986-022-00654-8.pdf |
| Ending Page | 11 |
| Page Count | 11 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 17437075 |
| DOI | 10.1186/s12986-022-00654-8 |
| Journal | Nutrition & Metabolism |
| Issue Number | 1 |
| Volume Number | 19 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2022-03-09 |
| Access Restriction | Open |
| Subject Keyword | Clinical Nutrition Metabolic Diseases Parenteral nutrition Drug metabolism-related genes Proteomics Fibroblast growth factor 19 Ileum organoids |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Endocrinology, Diabetes and Metabolism Nutrition and Dietetics |
| Journal Impact Factor | 3.9/2023 |
| 5-Year Journal Impact Factor | 4.3/2023 |
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