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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Bourquain, Daniel Schrick, Livia Tischer, Bernd Karsten Osterrieder, Klaus Schaade, Lars Nitsche, Andreas |
| Abstract | Zoonotic orthopoxvirus infections continue to represent a threat to human health. The disease caused by distinct orthopoxviruses differs in terms of symptoms and severity, which may be explained by the unique repertoire of virus factors that modulate the host’s immune response and cellular machinery. We report here on the construction of recombinant cowpox viruses (CPXV) which either lack the host range factor p28 completely or express truncated variants of p28. We show that p28 is essential for CPXV replication in macrophages of human or mouse origin and that the C-terminal RING finger domain of p28 is necessary to allow CPXV replication in macrophages. |
| Related Links | https://virologyj.biomedcentral.com/counter/pdf/10.1186/s12985-021-01640-x.pdf |
| Ending Page | 6 |
| Page Count | 6 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| DOI | 10.1186/s12985-021-01640-x |
| Journal | Virology Journal |
| Issue Number | 1 |
| Volume Number | 18 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2021-08-23 |
| Access Restriction | Open |
| Subject Keyword | Virology Orthopoxvirus Cowpox virus Host range p28 RING finger |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Infectious Diseases |
| Journal Impact Factor | 4/2023 |
| 5-Year Journal Impact Factor | 3.8/2023 |
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